Ke Hobane'ng ha U Lokela ho Reka Spermidine Powder? Ho Hlalositsoe Melemo ea Bohlokoa

Spermidine,e tsejoang hape e le spermidine, ke ntho ea triamine polyamine e fumanoang haholo limela tse kang koro, linaoa tsa soya le litapole, likokoana-hloko tse kang lactobacilli le bifidobacteria, le mefuta e sa tšoaneng ea liphoofolo. Spermidine ke hydrocarbon e nang le skeleton ea carbon e bōpehileng joaloka zigzag e entsoeng ka liathomo tsa carbon tse 7 le lihlopha tsa amino lipheletsong tse peli le bohareng.

Lipatlisiso tsa morao-rao li pakile hore spermidine e ameha mekhoeng ea bohlokoa ea bophelo e kang ho pheta-pheta ha DNA ea lisele, ho ngoloa ha mRNA, le phetolelo ea protheine, hammoho le mekhoa e mengata ea likokoana-hloko tse kang tšireletso ea 'mele le metabolism. E na le tšireletso ea pelo le methapo ea mali, anti-tumor, le taolo ea ho ruruha, joalo-joalo Mosebetsi oa bohlokoa oa likokoana-hloko.

Spermidine e nkoa e le activator e matla ea autophagy, mokhoa oa ho tsosolosa ka hare ho lisele tseo lisele tsa khale li inchafatsang le ho tsosolosa mosebetsi. Spermidine e bapala karolo ea bohlokoa tšebetsong ea lisele le ho phela. 'Meleng, spermidine e hlahisoa ho tsoa ho precursor putrescine, eo le eona e leng selelekela sa polyamine e 'ngoe e bitsoang spermine, eo hape e leng ea bohlokoa tšebetsong ea sele.

Spermidine le putrescine li susumetsa autophagy, tsamaiso e senyang litšila tsa intracellular le ho tsosolosa lisebelisoa tsa lisele 'me ke mokhoa oa ho laola boleng ba mitochondria, matla a matla a sele. Autophagy e senyeha ebe e lahla mitochondria e senyehileng kapa e nang le bothata, 'me ho lahla mitochondrial ke ts'ebetso e laoloang ka thata. Li-polyamine li khona ho tlama mefuta e mengata e fapaneng ea limolek'hule, e leng se etsang hore li fetohe. Ba ts'ehetsa lits'ebetso tse joalo ka kholo ea lisele, botsitso ba DNA, ho ata ha lisele, le apoptosis. Li-polyamine li bonahala li sebetsa ka mokhoa o ts'oanang le maemo a kholo nakong ea karohano ea lisele, ke ka lebaka leo putrescine le spermidine li bohlokoa ho kholo le ts'ebetsong ea lisele tse phetseng hantle.

Bafuputsi ba ithutile kamoo spermidine e sireletsang lisele ho tsoa khatellong ea oxidative, e ka senyang lisele le ho baka mafu a fapaneng. Ba fumane hore spermidine e kenya tšebetsong autophagy. Boithuto bo bonts'itse liphatsa tsa lefutso tse 'maloa tse anngoeng ke spermidine tse fokotsang khatello ea oxidative le ho khothaletsa autophagy liseleng tsena. Ho phaella moo, ba fumane hore ho thibela tsela ea mTOR, eo hangata e amehang ho thibela autophagy, ho ntlafatsa liphello tsa tšireletso tsa spermidine.

Ke lijo life tse nang le spermidine e ngata?

Spermidine ke polyamine ea bohlokoa. Ntle le ho hlahisoa ke 'mele oa motho ka boeona, mehloli ea lijo tse ngata le likokoana-hloko tsa mala le tsona ke litsela tsa bohlokoa tsa phepelo. Palo ea spermidine lijong tse fapaneng e fapana haholo, 'me kokoana-hloko ea koro ke mohloli o tsebahalang oa semela. Mehloli e meng ea lijo e kenyelletsa grapefruit, lihlahisoa tsa soya, linaoa, poone, lijo-thollo, lierekisi, lierekisi, pepere e tala, broccoli, lilamunu, tee e tala, bran ea raese le pepere e ncha e tala. Ho feta moo, lijo tse kang li-mushroom tsa shiitake, peo ea amaranth, cauliflower, chisi e hōlileng tsebong le durian le tsona li na le spermidine.

Ke habohlokoa ho hlokomela hore lijo tsa Mediterranean li na le lijo tse ngata tse nang le spermidine, tse ka thusang ho hlalosa ketsahalo ea "blue zone" moo batho ba phelang nako e telele libakeng tse itseng. Leha ho le joalo, bakeng sa batho ba sa khoneng ho ja spermidine e lekaneng ka lijo, li-supplement tsa spermidine ke mokhoa o mong o sebetsang. The spermidine ka li-supplement tsena ke molek'hule e ts'oanang ea tlhaho, e etsang hore e be mokhoa o mong o sebetsang.

putrescine ke eng?

Tlhahiso ea putrescine e kenyelletsa litsela tse peli, tseo ka bobeli li qalang ka amino acid arginine. Tseleng ea pele, arginine e qala ho fetoloa ho agmatine e hlahisoang ke arginine decarboxylase. Ka mor'a moo, agmatine e fetoloa hape ho N-carbamoylputrescine ka ketso ea agmatine iminohydroxylase. Qetellong, N-carbamoylputrescine e fetoloa putrescine, e phethela tšebetso ea phetoho. Tsela ea bobeli e batla e le bonolo, e fetola ka ho toba arginine ho ornithine, ebe e fetola ornithine ho putrescine ka ketso ea ornithine decarboxylase. Le hoja litsela tsena tse peli li na le mehato e fapaneng, ka bobeli li qetella li finyella phetoho ho tloha ho arginine ho ea putrescine.

Putrescine ke diamine e fumanehang lithong tse fapaneng tse kang manyeme, thymus, letlalo, boko, popelo le mae a bomme. Putrescine e boetse e fumanoa hangata lijong tse kang kokoana-hloko ea koro, pepere e tala, linaoa tsa soya, li-pistachios le lilamunu. Liphuputso tsa morao-rao li bontšitse hore putrescine ke ntho ea bohlokoa e laolang metabolism e ka sebelisanang le li-macromolecules tsa likokoana-hloko tse kang DNA, RNA, li-ligands tse sa tšoaneng (joaloka β1 le β2 adrenergic receptors), le li-membrane receptors. , e lebisang letotong la liphetoho tsa 'mele kapa tsa pathological' meleng.

Tšusumetso ea spermidine

Mosebetsi oa Antioxidant: Spermidine e na le ts'ebetso e matla ea antioxidant 'me e ka itšoara ka li-radicals tsa mahala ho fokotsa tšenyo ea oxidative ho lisele tse bakoang ke li-radicals tsa mahala. 'Meleng, spermidine e ka boela ea khothalletsa polelo ea li-enzyme tsa antioxidant le ho matlafatsa matla a antioxidant.

Taolo ea metabolism ea matla: Spermidine e ameha ho laola metabolism ea matla ea lintho tse phelang, e ka khothalletsa ho monya le ho sebelisoa ha tsoekere ka mor'a ho ja lijo, 'me e ama karo-karolelano ea metabolism ea aerobic le anaerobic metabolism ka ho laola katleho ea tlhahiso ea matla a mitochondrial.

phello e khahlanong le ho ruruha

Spermidine e na le liphello tse khahlanong le ho ruruha 'me e ka laola polelo ea lintlha tsa ho ruruha le ho fokotsa ketsahalo ea ho ruruha ho sa foleng. Haholo-holo e amanang le tsela ea nuclear factor-κB (NF-κB).

Khōlo, nts'etsopele le taolo ea 'mele ea ho itšireletsa mafung: Spermidine e boetse e phetha karolo ea bohlokoa khōlong, nts'etsopele le taolo ea ho itšireletsa mafung. E ka khothalletsa secretion ea kholo ea hormone 'meleng oa motho le ho thusa ho ntlafatsa tsoelo-pele ea lisele tse sa tšoaneng le litho tsa' mele. Ka nako e ts'oanang, taolong ea 'mele ea ho itšireletsa mafung, spermidine e ntlafatsa ho hanyetsa' mele ho livaerase le mafu ka ho laola tlhahiso ea lisele tse tšoeu tsa mali le ho khothalletsa ho tlosoa ha mefuta ea oksijene e sebetsang.

Ho lieha ho tsofala: Spermidine e ka khothaletsa autophagy, mokhoa oa ho hloekisa ka har'a lisele tse thusang ho tlosa li-organelle tse senyehileng le liprotheine, kahoo li liehisa botsofali.

Taolo ea lisele tsa Glial: Spermidine e bapala karolo ea bohlokoa ea taolo liseleng tsa glial. E ka kenya letsoho lits'ebetsong tsa lipontšo tsa lisele le likamano tse sebetsang pakeng tsa lisele tsa methapo, 'me e phetha karolo ea bohlokoa ea taolo ho nts'etsopele ea neuron, phetisetso ea synaptic, le ho hanyetsa lefu la pelo.

Tšireletso ea pelo: Lebaleng la pelo, spermidine e ka fokotsa ho bokellana ha lipid ka har'a li-atherosclerotic plaques, ea fokotsa hypertrophy ea pelo, le ho ntlafatsa ts'ebetso ea diastolic, kahoo ea fumana tšireletso ea pelo. Ho feta moo, ho ja spermidine ho ntlafatsa khatello ea mali le ho fokotsa lefu la pelo le lefu la pelo.

Ka 2016, lipatlisiso tse phatlalalitsoeng ho Atherosclerosis li netefalitse hore spermidine e ka fokotsa ho bokellana ha lipid ho li-atherosclerotic plaque. Selemong sona seo, phuputso e phatlalalitsoeng ho Nature Medicine e netefalitse hore spermidine e ka fokotsa hypertrophy ea pelo le ho ntlafatsa ts'ebetso ea diastolic, kahoo e sireletsa pelo le ho lelefatsa bophelo ba litoeba.

Ntlafatsa lefu la Alzheimer

Ho kenngoa ha spermidine ho molemo bakeng sa ts'ebetso ea mohopolo oa motho. Sehlopha sa Moprofesa Reinhart oa Australia se fumane hore phekolo ea spermidine e ka ntlafatsa ts'ebetso ea kelello ea maqheku. Boithuto bo ile ba amohela moralo o nang le litsi tse ngata tse foufetseng 'me tsa ngolisa maqheku a 85 mahaeng a maqheku a 6, ba neng ba arotsoe ka lihlopha tse peli mme ba sebelisa litekanyetso tse fapaneng tsa spermidine. Mosebetsi oa bona oa kelello o ile oa hlahlojoa ka liteko tsa mohopolo 'me oa aroloa ka lihlopha tse' nè: ha ho 'dementia', 'dementia' e bonolo, 'dementia' e itekanetseng le 'dementia' e matla. Lisampole tsa mali li ile tsa bokelloa ho lekola bongata ba spermidine maling a bona. Liphello li bontšitse hore mahloriso a spermidine a amana haholo le ts'ebetso ea ts'ebetso ea kelello sehlopheng se seng sa 'dementia', 'me boemo ba kelello ba batho ba hōlileng ba nang le 'dementia' bo bobebe ho isa ho bo itekanetseng bo ile ba ntlafala haholo ka mor'a ho noa tekanyo e phahameng ea spermidine.

Autophagy

Spermidine e ka khothalletsa ho itšehla thajana, joalo ka mokhoa oa ho thibela ho thibela lefu la mTOR (sepheo sa rapamycin). Ka ho khothaletsa autophagy, e thusa ho tlosa organelles le liprotheine tse senyehileng liseleng le ho boloka bophelo bo botle ba lisele.

Spermidine hydrochloride e sebelisoa libakeng tse fapaneng

Sebakeng sa meriana, spermidine hydrochloride e sebelisoa e le lithethefatsi tsa hepatoprotective tse ka ntlafatsang mosebetsi oa sebete le ho fokotsa tšenyo ea sebete. Ho feta moo, spermidine hydrochloride e ka sebelisoa ho phekola maemo a kang k'holeseterole e phahameng, hypertriglyceridemia le lefu la pelo.

Spermidine hydrochloride e sebetsa ka ho fokotsa maemo a plasma homocysteine ​​​​(Hcy), ka hona e fokotsa kotsi ea lefu la pelo. Liphuputso li bontšitse hore spermidine hydrochloride e ka khothalletsa metabolism ea Hcy le ho fokotsa kotsi ea lefu la pelo ka ho fokotsa maemo a Hcy a plasma.

Phuputso e mabapi le liphello tsa spermidine hydrochloride kotsing ea lefu la pelo e bontšitse hore spermidine hydrochloride e ka fokotsa maemo a plasma ea Hcy, kahoo e fokotsa kotsi ea lefu la pelo. Phuputsong, bafuputsi ba arola barupeluoa ka lihlopha tse peli, 'me e mong a fumana spermidine hydrochloride supplementation ha e mong a fumana placebo.

Liphetho tsa thuto li bonts'itse hore barupeluoa ba fumaneng spermidine hydrochloride supplementation ba ne ba e-na le maemo a tlase haholo a plasma ea Hcy le phokotso e ts'oanang ea kotsi ea lefu la pelo. Ho feta moo, ho na le lithuto tse ling tse tšehetsang karolo ea spermidine hydrochloride ho fokotsa kotsi ea lefu la pelo.

Sebakeng sa lijo, spermidine hydrochloride e sebelisoa e le sehlahisoa sa tatso le se monate ho ntlafatsa tatso ea lijo le ho boloka mongobo oa lijo. Ho feta moo, spermidine hydrochloride e ka boela ea sebelisoa e le tlatsetso ea phepo ho ntlafatsa sekhahla sa kholo le boleng ba mesifa ea liphoofolo.

Ho litlolo, spermidine hydrochloride e sebelisoa e le humectant le antioxidant ho boloka mongobo oa letlalo le ho fokotsa tšenyo ea mahala. Ho phaella moo, spermidine hydrochloride e ka boela ea sebelisoa ka litlolo tse sireletsang letsatsi ho fokotsa tšenyo ea mahlaseli a kotsi letlalong.

Tšimong ea temo, spermidine hydrochloride e sebelisoa e le taolo ea kholo ea limela ho khothaletsa kholo ea lijalo le ho eketsa chai.