Ke Hobane'ng ha U Lokela ho Reka Phofo ea Spermidine? Melemo ea Bohlokoa e Hlalositsoe

Spermidine,e tsejoang hape e le spermidine, ke ntho ea triamine polyamine e fumanehang haholo limela tse kang koro, soya le litapole, likokoana-hloko tse kang lactobacilli le bifidobacteria, le lisele tse fapaneng tsa liphoofolo. Spermidine ke hydrocarbon e nang le masapo a carbon a bōpehileng joaloka zigzag a entsoeng ka liathomo tse 7 tsa carbon le lihlopha tsa amino lipheletsong ka bobeli le bohareng.

Diphuputso tsa sejwalejwale di pakile hore spermidine e ameha ditshebetsong tsa bohlokwa tsa bophelo tse kang ho ikatisa ha DNA ya sele, ho ngolwa ha mRNA, le phetolelo ya protheine, hammoho le ditshebetso tse ngata tsa pathophysiological tse kang tshireletso ya kgatello ya mmele le metabolism. E na le tshireletso ya pelo le methapo ya kutlo, e lwantshang hlahala, le taolo ya ho ruruha, jj. Mosebetsi wa bohlokwa wa baeloji.

Spermidine e nkoa e le sebui se matla sa autophagy, e leng mokhoa oa ho sebelisa hape lisele tseo lisele tsa khale li itsosolosang ka tsona le ho fumana tšebetso hape. Spermidine e bapala karolo ea bohlokoa mosebetsing oa sele le ho phela ha eona. 'Meleng, spermidine e hlahisoa ho tsoa ho putrescine ea eona e ka pele ho eona, eo hape e leng selelekela sa polyamine e 'ngoe e bitsoang spermine, e leng eona ea bohlokoa mosebetsing oa sele.

Spermidine le putrescine li hlohlelletsa autophagy, e leng sistimi e qhaqhang litšila tse ka hare ho sele le ho sebelisa hape likarolo tsa sele 'me ke mokhoa oa taolo ea boleng bakeng sa mitochondria, e leng matla a sele. Autophagy e qhaqha le ho lahla mitochondria e senyehileng kapa e nang le sekoli, 'me ho lahla mitochondria ke ts'ebetso e laoloang ka thata. Li-polyamine li khona ho tlama mefuta e mengata e fapaneng ea limolek'hule, e leng se etsang hore li be le mekhoa e mengata. Li tšehetsa lits'ebetso tse kang kholo ea sele, botsitso ba DNA, ho ata ha sele le apoptosis. Li-polyamine li bonahala li sebetsa ka tsela e tšoanang le lintlha tsa kholo nakong ea karohano ea sele, ke ka lebaka leo putrescine le spermidine li leng bohlokoa kholong le ts'ebetsong ea lisele tse phetseng hantle.

Bafuputsi ba ithutile kamoo spermidine e sireletsang lisele khatellong ea oxidative, e ka senyang lisele le ho lebisa mafung a fapaneng. Ba fumane hore spermidine e kenya tšebetsong autophagy. Phuputso e hlwaile liphatsa tse 'maloa tsa bohlokoa tse angoang ke spermidine tse fokotsang khatello ea oxidative le ho khothalletsa autophagy liseleng tsena. Ho phaella moo, ba fumane hore ho thibela tsela ea mTOR, eo hangata e amehang ho thibeleng autophagy, ho ntlafatsa le ho feta liphello tsa tšireletso tsa spermidine.

Ke lijo life tse nang le spermidine e ngata?

Spermidine ke polyamine ea bohlokoa. Ntle le ho hlahisoa ke 'mele oa motho ka boeona, mehloli ea eona e mengata ea lijo le likokoana-hloko tsa mala le tsona ke litsela tsa bohlokoa tsa phepelo. Palo ea spermidine lijong tse fapaneng e fapana haholo, 'me kokoana-hloko ea koro ke mohloli o tsebahalang oa limela. Mehloli e meng ea lijo e kenyelletsa grapefruit, lihlahisoa tsa soya, linaoa, poone, lijo-thollo tse felletseng, chickpeas, lierekisi, pepere e tala, broccoli, lilamunu, tee e tala, raese bran le pepere e tala e foreshe. Ho phaella moo, lijo tse kang li-mushroom tsa shiitake, peo ea amaranth, cauliflower, chisi e butsoitseng le durian le tsona li na le spermidine.

Hoa hlokomeleha hore lijo tsa Mediterranean li na le lijo tse ngata tse nang le spermidine e ngata, e leng se ka thusang ho hlalosa ketsahalo ea "sebaka se seputsoa" moo batho ba phelang nako e telele libakeng tse itseng. Leha ho le joalo, bakeng sa batho ba sa khoneng ho ja spermidine e lekaneng ka lijo, li-supplement tsa spermidine ke mokhoa o mong o sebetsang. Spermidine e ka har'a li-supplement tsena ke molek'hule e tšoanang ea tlhaho, e leng se etsang hore e be mokhoa o mong o sebetsang.

Putrescine ke eng?

Tlhahiso ea putrescine e kenyelletsa litsela tse peli, tseo ka bobeli li qalang ka amino acid arginine. Tseleng ea pele, arginine e fetoloa pele ho agmatine e susumetsoang ke arginine decarboxylase. Ka mor'a moo, agmatine e fetoloa ho ea pele ho N-carbamoylputrescine ka ketso ea agmatine iminohydroxylase. Qetellong, N-carbamoylputrescine e fetoloa ho ba putrescine, e phethela ts'ebetso ea phetoho. Tsela ea bobeli e bonolo haholo, e fetola arginine ka ho toba ho ba ornithine, ebe e fetola ornithine ho ba putrescine ka ketso ea ornithine decarboxylase. Le hoja litsela tsena tse peli li na le mehato e fapaneng, ka bobeli li qetella li fihletse phetoho ho tloha ho arginine ho ea ho putrescine.

Putrescine ke diamine e fumanoang lithong tse fapaneng tse kang pancreas, thymus, letlalo, boko, popelo le mae a bomme. Putrescine e boetse e fumanoa hangata lijong tse kang koro germ, pepere e tala, soya, pistachios le lilamunu. Lithuto tsa morao tjena li bontšitse hore putrescine ke ntho ea bohlokoa e laolang metabolism e ka sebelisanang le limolek'hule tsa baeloji tse kang DNA e tjhajisitsoeng hampe, RNA, li-ligand tse fapaneng (tse kang β1 le β2 adrenergic receptors), le liprotheine tsa lera. , e leng se lebisang letotong la liphetoho tsa 'mele kapa tsa pathological' meleng.

Phello ea Spermidine

Tšebetso ea Antioxidant: Spermidine e na le ts'ebetso e matla ea antioxidant 'me e ka arabela le li-free radicals ho fokotsa tšenyo ea oxidative liseleng tse bakoang ke li-free radicals. 'Meleng, spermidine e ka boela ea khothalletsa tlhahiso ea li-enzyme tsa antioxidant le ho ntlafatsa bokhoni ba antioxidant.

Taolo ea metabolism ea matla: Spermidine e ameha ho laoleng metabolism ea matla ea lintho tse phelang, e ka khothaletsa ho monngoa le ho sebelisoa ha tsoekere ka mor'a ho ja, 'me e ama karolelano ea metabolism ea aerobic le metabolism ea anaerobic ka ho laola katleho ea tlhahiso ea matla a mitochondrial.

phello e khahlanong le ho ruruha

Spermidine e na le ditlamorao tse thibelang ho ruruha mme e ka laola tlhahiso ya mabaka a ho ruruha le ho fokotsa ho hlaha ha ho ruruha ho sa foleng. Haholo-holo e amana le tsela ya nuclear factor-κB (NF-κB).

Kgolo, ntshetsopele le taolo ya sesole sa mmele: Spermidine e boetse e bapala karolo ya bohlokwa kgolong, ntshetsopeleng le taolong ya sesole sa mmele. E ka kgothaletsa tlhahiso ya hormone ya kgolo mmeleng wa motho mme ya thusa ho ntlafatsa ntshetsopele ya dinama tse fapaneng le ditho tsa mmele. Ka nako e ts'oanang, taolong ya sesole sa mmele, spermidine e eketsa ho hanyetsa ha mmele dikokwana-hloko le mafu ka ho laola tlhahiso ya disele tse tshweu tsa madi le ho kgothaletsa ho tloswa ha mefuta ya oksijene e arabelang.

Liehisa botsofali: Spermidine e ka khothalletsa autophagy, e leng mokhoa oa ho hloekisa ka hare ho lisele o thusang ho tlosa li-organelle le liprotheine tse senyehileng, ka hona e liehisa botsofali.

Taolo ea lisele tsa Glial: Spermidine e bapala karolo ea bohlokoa ea taolo liseleng tsa glial. E ka nka karolo lits'ebetsong tsa lipontšo tsa lisele le likamanong tse sebetsang lipakeng tsa lisele tsa methapo, 'me e bapala karolo ea bohlokoa ea taolo nts'etsopele ea li-neuron, phetiso ea synaptic, le ho hanyetsa neuropathy.

Tšireletso ea pelo le methapo ea mali: Lefapheng la pelo le methapo ea mali, spermidine e ka fokotsa ho bokellana ha mafura maling a atherosclerotic plaques, ea fokotsa hypertrophy ea pelo le ho ntlafatsa ts'ebetso ea diastolic, ka hona ea finyella tšireletso ea pelo. Ho phaella moo, ho ja spermidine lijong ho ntlafatsa khatello ea mali le ho fokotsa ho kula ha pelo le lefu.

Ka 2016, phuputso e phatlalalitsoeng ho Atherosclerosis e tiisitse hore spermidine e ka fokotsa ho bokellana ha mafura ka har'a li-plaque tsa atherosclerotic. Selemong sona seo, phuputso e phatlalalitsoeng ho Nature Medicine e tiisitse hore spermidine e ka fokotsa hypertrophy ea pelo le ho ntlafatsa ts'ebetso ea diastolic, ka hona e sireletsa pelo le ho lelefatsa bophelo ba litoeba.

Ntlafatsa lefu la Alzheimer

Ho noa spermidine ho molemo bakeng sa ts'ebetso ea mohopolo oa motho. Sehlopha sa Moprofesa Reinhart oa Australia se fumane hore kalafo ea spermidine e ka ntlafatsa ts'ebetso ea kelello ea batho ba hōlileng. Phuputso e amohetse moralo oa li-multi-found double-found mme ea ngolisa batho ba hōlileng ba 85 malapeng a 6 a tlhokomelo ea batho ba hōlileng, ba ileng ba aroloa ka mokhoa o sa reroang ka lihlopha tse peli 'me ba sebelisa litekanyo tse fapaneng tsa spermidine. Ts'ebetso ea bona ea kelello e ile ea hlahlojoa ka liteko tsa mohopolo 'me ea aroloa ka lihlopha tse 'ne: ho se be le dementia, dementia e bobebe, dementia e itekanetseng le dementia e matla. Lisampole tsa mali li ile tsa bokelloa ho lekola khatello ea spermidine maling a bona. Liphetho li bontšitse hore khatello ea spermidine e ne e amana haholo le ts'ebetso ea kelello sehlopheng se seng sa dementia, 'me boemo ba kelello ba batho ba hōlileng ba nang le dementia e fokolang ho isa ho e itekanetseng bo ntlafetse haholo ka mor'a ho noa tekanyo e phahameng ea spermidine.

Autophagy

Spermidine e ka kgothaletsa autophagy, jwalo ka tsela ya thibelo ya mTOR (target of rapamycin). Ka ho kgothaletsa autophagy, e thusa ho tlosa di-organelle tse senyehileng le diprotheine ka hara disele le ho boloka bophelo bo botle ba sele.

Spermidine hydrochloride e sebelisoa masimong a fapaneng

Lefapheng la meriana, spermidine hydrochloride e sebelisoa e le moriana o sireletsang sebete o ka ntlafatsang ts'ebetso ea sebete le ho fokotsa tšenyo ea sebete. Ho phaella moo, spermidine hydrochloride e ka sebelisoa ho phekola maemo a kang k'holeseterole e phahameng, hypertriglyceridemia le lefu la pelo.

Spermidine hydrochloride e sebetsa ka ho fokotsa maemo a plasma homocysteine ​​​​(Hcy), ka hona e fokotsa kotsi ea lefu la pelo le methapo ea mali. Lithuto li bontšitse hore spermidine hydrochloride e ka khothaletsa metabolism ea Hcy le ho fokotsa kotsi ea lefu la pelo le methapo ea mali ka ho fokotsa maemo a plasma Hcy.

Phuputso mabapi le liphello tsa spermidine hydrochloride kotsing ea lefu la pelo le methapo ea mali e bontšitse hore spermidine hydrochloride e ka fokotsa maemo a Hcy maling, ka hona ea fokotsa kotsi ea lefu la pelo le methapo ea mali. Phuputsong ena, bafuputsi ba arotse barupeluoa ka lihlopha tse peli, e 'ngoe e fumana tlatsetso ea spermidine hydrochloride 'me e 'ngoe e fumana placebo.

Liphetho tsa thuto li bontšitse hore barupeluoa ba fumaneng tlatsetso ea spermidine hydrochloride ba ne ba e-na le maemo a tlaase haholo a Hcy plasma le phokotso e tsamaellanang le kotsi ea lefu la pelo le methapo ea mali. Ho feta moo, ho na le lithuto tse ling tse tšehetsang karolo ea spermidine hydrochloride ho fokotseng kotsi ea lefu la pelo le methapo ea mali.

Lefapheng la dijo, spermidine hydrochloride e sebediswa e le ntho e ntlafatsang tatso le humectant ho ntlafatsa tatso ya dijo le ho boloka mongobo wa dijo. Ho feta moo, spermidine hydrochloride e ka sebediswa e le sehlomathiso sa phepo ho ntlafatsa sekgahla sa kgolo le boleng ba mesifa ya diphoofolo.

Litlolong, spermidine hydrochloride e sebelisoa e le humectant le antioxidant ho boloka mongobo oa letlalo le ho fokotsa tšenyo ea li-free radical. Ho phaella moo, spermidine hydrochloride e ka boela ea sebelisoa li-sunscreen ho fokotsa tšenyo ea mahlaseli a ultraviolet letlalong.

Lefapheng la temo, spermidine hydrochloride e sebediswa e le taolo ya kgolo ya dimela ho kgothaletsa kgolo ya dijalo le ho eketsa chai.