Oleoylethanolamide (OEA) moetsi oa phofo CAS No.: 111-58-0 98%,85% bohloeki min. bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | Oleoyl ethanolamide |
| Lebitso le leng | N-oleoyl ethanolamine; N-(2-hydroxyethyl)-,(Z) -9-Octadecenamide |
| Nomoro ea CAS. | 111-58-0 |
| Mokhoa oa limolek'hule | C20H39NO2 |
| Boima ba molek'hule | 325.53 |
| Bohloeki | 98.0%, 85.0% |
| Ponahalo | Phofo e ntle ea kristale e tšoeu |
| Ho paka | 1kg / mokotla, 25kg / moropa |
| Kopo | Phokotso ea bohloko, anti-inflammatory |
Kenyelletso ea sehlahisoa
Oleoylethanolamide ke motsoako oa bobeli oa amide o entsoeng ka lipophilic oleic acid le hydrophilic ethanolamine. Oleoylethanolamide le eona ke molek'hule ea lipid e hlahang ka tlhaho liphatseng tse ling tsa liphoofolo le limela. E fumaneha haholo liphatseng tsa liphoofolo le tsa limela joalo ka phofo ea cocoa, soya le linate, empa litaba tsa eona li tlase haholo. Ke feela ha tikoloho ea kantle e fetoha kapa lijo li hlohlelletsoa, lisele tsa lisele tsa 'mele Ke feela ka nako eo ho tla hlahisoa bongata ba ntho ena.
Mochesong oa kamore, Oleoylethanolamide ke ntho e tiileng e tšoeu e nang le ntlha e qhibilihang e ka bang 50°C. E qhibiliha habonolo ka lihlapolli tse tahang tse kang methanol le ethanol, 'me e qhibiliha habonolo ka har'a lihlapolli tse se nang polar tse kang n-hexane le ether, 'me ha e qhibilihe metsing. OEA ke molek'hule ea amphiphilic eo ka tloaelo e sebelisoang e le setlolo le se hloekisang indastering ea lik'hemik'hale. Leha ho le joalo, lipatlisiso tse ling li fumane hore OEA e ka sebetsa e le molek'hule e bonts'ang lipid ka har'a axis ea boko le ho bonts'a letoto la mesebetsi ea tlhaho 'meleng, ho kenyelletsa: ho laola takatso ea lijo, ho ntlafatsa metabolism ea lipid, ho matlafatsa mohopolo le temoho le mesebetsi e meng. Har'a bona, mesebetsi ea Oleoylethanolamide ea ho laola takatso ea lijo le ho ntlafatsa metabolism ea lipid e fumane tlhokomelo e kholo.
Oleoylethanolamide e ka laola ho kenngoa ha lijo le matla a homeostasis ka ho kenya tšebetsong peroxisome proliferator-activated receptor-α. Ho phaella moo, Oleoylethanolamide e bonts'a mesebetsi e meng e amanang le bophelo bo botle, ho kenyelletsa le ho fetola mokhoa oa ho fetola phetoho tseleng ea lysosomal-to-nuclear e amanang le taolo ea nako e telele le ho sireletsa methapo e laolang boitšoaro bo sithabetsang. Lipatlisiso li boetse li fana ka maikutlo a hore Oleoylethanolamide e ka ba le liphello tsa neuroprotective. Mehlala ea liphoofolo, e fumanoe e fokotsa tšenyo e bakoang ke stroke le kotsi e sithabetsang ea boko. Phello ea taolo ea Oleoylethanolamide e bakoa ke ho tlama ha eona ho PPARα, e fokotsehang ka retinoid X receptor (RXR) mme e e sebelisa e le ntho e matla ea ho ngoloa e amehang ho kopantsoeng ha matla a homeostasis, lipid metabolism, autophagy le ho ruruha. liphofu tse tlase.
Sebopeho
(1) Bohloeki bo phahameng: OEA e ka fumana lihlahisoa tse hloekileng ka ho hloekisa mekhoa ea tlhahiso. Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: OEA e pakiloe e sireletsehile bakeng sa 'mele oa motho.
(3) Botsitso: OEA e na le botsitso bo botle mme e ka boloka ts'ebetso ea eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
(4) Ho monya habonolo: OEA e ka monngoa kapele ke ’mele oa motho ’me ea abeloa lisele le litho tse fapaneng.
Lisebelisoa
Oleoylethanolamide ke lipid ea tlhaho ea ethanolamide e sebelisoang e le moralo oa lijo le taolo ea boima ba 'mele mefuteng e fapaneng ea vertebrate. Ke metabolite ea oleic acid e entsoeng ka maleng a manyane a motho. Oleylethanolamide (OEA) ke molek'hule e laolang lipid metabolism le homeostasis ea matla. E khomarela li-receptor tsa PPAR Alpha mme e thusa ho laola lintlha tse 'nè: tlala, mafura a' mele, k'holeseterole le boima ba 'mele. PPAR Alpha e emela peroxide proliferator-activated receptor alpha, 'me bioactive lipid amide oleoylethanolamide (OEA) e na le mefuta e sa tšoaneng e ikhethang ea homeostatic, ho akarelletsa le ts'ebetso e khahlanong le ho ruruha, mokhoa oa ho itšireletsa mafung, le liphello tsa antioxidant.
