1-Methylnicotinamide Chloride Nomoro ea CAS:1005-24-9
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | 1-Methylnicotinamide chloride |
| Lebitso le leng | N-Methylnicotinamide chloride；NMN-Cl；1-MNA chloride；3-carbamoyl-1-methyl-pyridinium chloride |
| Nomoro ea CAS | 1005-24-9 |
| Foromo ea limolek'hule | C7H9N2OCl |
| Boima ba limolek'hule | 172.61 |
| Bohloeki | 98.5% |
| Ponahalo | Bosweu – bo sa soeufalang, bo tiileng ba kristalephofo |
| Ho paka | 1kg/mokotla; 25kg/moropa |
| Kopo | cea malietlhahlobomli-ateri |
Selelekela sa sehlahisoa
1-Methylnicotinamide chloride ke motsoako o nang le methylated oa nicotinamide, o khetholloang ka sebopeho se tsitsitseng sa letsoai la ammonium la quaternary. E sebetsa e le karolo ea bohlokoa ea ho ithuta metabolism ea nicotinamide. Ho qhibiliha ha eona metsing le botsitso ba lik'hemik'hale ho etsa hore e tšoanelehe e le motsoako oa sesebelisoa bakeng sa lipatlisiso tsa biochemical.
1-MNA ke ntho e hlahang ka tlhaho 'meleng oa motho, e sebetsang e le sehlahisoa se tloaelehileng sa metabolism ea niacin. E le karolo e bohareng tseleng ena ea metabolism, 1-MNA e sebetsoa hape ke aldehyde oxidase ho hlahisa li-metabolite tse latelang tse kang N-methyl-2-pyridone-5-carboxamide (2PY) le N-methyl-4-pyridone-3-carboxamide (4PY), tseo qetellong li ntšoang ka har'a tsamaiso ea moroto.
1-Methylnicotinamide chloride ke motsoako o nang le methylated oa nicotinamide, o khetholloang ka sebopeho se tsitsitseng sa letsoai la ammonium la quaternary. E sebetsa e le karolo ea bohlokoa ea ho ithuta metabolism ea nicotinamide. Ho qhibiliha ha eona metsing le botsitso ba lik'hemik'hale ho etsa hore e tšoanelehe e le motsoako oa sesebelisoa bakeng sa lipatlisiso tsa biochemical.
1-MNA ke ntho e hlahang ka tlhaho 'meleng oa motho, e sebetsang e le sehlahisoa se tloaelehileng sa metabolism ea niacin. E le karolo e bohareng tseleng ena ea metabolism, 1-MNA e sebetsoa hape ke aldehyde oxidase ho hlahisa li-metabolite tse latelang tse kang N-methyl-2-pyridone-5-carboxamide (2PY) le N-methyl-4-pyridone-3-carboxamide (4PY), tseo qetellong li ntšoang ka har'a tsamaiso ea moroto.
Tšobotsi
(1) Ho qhibiliha ha metsi: E qhibiliha habonolo metsing le li-solvents tsa tlhaho tsa polar.
(2) Botsitso: E tsitsitse tlas'a maemo a mocheso oa kamore empa e hloka polokelo libakeng tse sa keneleng mongobo.
(3) Polokeho: European Union e entse tlhahlobo ea saense ea 1-MNA e le motsoako o mocha oa lijo. Ho latela Molao oa EU (EC) No 258/97, 1-MNA e nkoa e sireletsehile bakeng sa tšebeliso, ka tekanyo e phahameng e khothaletsoang ea motho e moholo ea 58 mg letsatsi le letsatsi, haholo-holo e reretsoeng ho sebelisoa lijong tse tlatsetsang.
Likopo
1-Methylnicotinamide chloride (e khutsufalitsoeng e le MNC) ke motsoako o nang le methylated oa nicotinamide. Ho fumanoa ha 1-MNA ho ka etsoa ka mekhoa e kang high-performance liquid chromatography (HPLC) le enzyme-linked immunosorbent assay (ELISA). E bontša bokhoni ba ho sebelisoa ka har'a makala a lijo le lihlahisoa tsa bophelo bo botle. Indastering ea lijo, e ka sebetsa e le antioxidant ho liehisa ho oxidation ea lipid le ho boloka boleng ba lijo. Ka lebaka la litšobotsi tsa eona tsa sebopeho, e ka boela ea sebetsa e le motsoako o sebetsang lijong tse matlafalitsoeng ka phepo e nepahetseng. Ho feta moo, 1-MNA e bontša mesebetsi taolong ea metabolism le ntlafatso ea maemo a 'mele, e e fa boleng ba nts'etsopele lijong tse sebetsang le li-supplement tsa lijo tse nang le litletlebo tsa bophelo bo botle.
Tlhahlobo ea EU e fihletse qeto ea hore ho noa 58 mg ea 1-MNA letsatsi le letsatsi ho tsoa li-supplement tsa lijo ho ka etsahala hore ho se lebise liphellong tse mpe bophelong ba batho, 'me e kenyelelitsoe ka molao lethathamong la lijo tse ncha tsa EU.
Jwalo ka molek'hule ya bohlokwa e sebetsang ka tlhaho le tekanyetso ya ditshupiso, 1-methylnicotinamide chloride e na le menyetla e pharaletseng ya tshebediso dipatlisisong tsa saense, ntshetsopeleng ya meriana, le indastering ya tlatsetso ya dijo. Tlhahlobo ya yona ya polokeho e hlalositsweng hantle le mesebetsi e fapaneng ya baeloji e e beha e le taba ya bohlokwa bakeng sa dipatlisiso le karolo ya dikopo tse fapaneng.
