Moetsi oa phofo ea Riboside ea 1,4-DihydronicotinaMide Nomoro ea CAS:19132-12-8 Bohloeki ba 98% bonyane bakeng sa metsoako ea tlatsetso
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | 1,4-DihydronicotinaMide Riboside |
| Lebitso le leng | 1,4-DIHYDRONICOTINAMIDE RIBOSIDE1-[(3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,4-dihydropyridine-3-carboxamideSCHEMBL188493711-[(3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-4H-PYRIDINE-3-CARBOXAMIDE |
| Nomoro ea CAS | 19132-12-8 |
| Foromo ea limolek'hule | C11H16N2O5 |
| Boima ba limolek'hule | 256.26 |
| Bohloeki | 98% |
| Ponahalo | Phofo e tšoeu |
| Ho paka | 1kg/mokotla; 25kg/moropa |
| Kopo | Lisebelisoa tse tala tsa tlatsetso ea lijo |
Selelekela sa sehlahisoa
1,4-dihydronicotinamide riboside, e tsejoang hape e le NRH.Mofuta o fokotsehileng oa NRH ke selelekela se matla sa NAD+ se thusang ho tlatsa maemo a sona ka seleng.
Sa pele le sa bohlokoa, ho bohlokoa ho utloisisa karolo ea NAD+ 'meleng. NAD+ ke coenzyme e amehang lits'ebetsong tse ngata tsa sele, ho kenyeletsoa metabolism ea matla, tokiso ea DNA le tlhahiso ea liphatsa tsa lefutso. Ha re ntse re tsofala, maemo a rona a NAD+ aa fokotseha, e leng se 'nileng sa ameha ts'ebetsong ea botsofali le mafu a amanang le botsofali. Sena se lebisitse thahasellong e ntseng e hola ea ho khetholla limolek'hule tse ka eketsang maemo a NAD+ 'meleng,' me 1,4-dihydronicotinamide riboside ke e 'ngoe ea limolek'hule tse joalo.
1,4-dihydronicotinamide riboside ke selelekela se matla sa NAD+, 'me lipatlisiso li bontšitse hore e ka phahamisa maemo a NAD+ ka katleho liseleng. Sena se lebisitse ho menyenyetsi ea hore tlatsetso ea 1,4-dihydronicotinamide riboside e ka ba le bokhoni ba kalafo maemong a fapaneng a bophelo bo botle, ho kenyeletsoa le mathata a metabolism, mafu a ho senyeha ha methapo ea kutlo, le ho fokotseha ho amanang le botsofali.
Ha e le hantle, ho na le bopaki bo bontšang hore 1,4-dihydronicotinamide riboside e ka ba le katleho e kholo ho feta molek'hule ea eona ea motsoali, nicotinamide riboside, ka ho eketsa maemo a NAD+. Lebaka ke hobane 1,4-dihydronicotinamide riboside ke sesebelisoa se fokotsang matla haholoanyane, ho bolelang hore se betere ho faneng ka lielektrone tseleng ea tlhahiso ea NAD+. Ka lebaka leo, e na le bokhoni ba ho fepa tlhahiso ea NAD+ ea sele ka katleho.
Ntle le karolo ea eona ho NAD+ biosynthesis, 1,4-dihydronicotinamide riboside e boetse e na le thepa ea antioxidant. Khatello ea oxidative, e bakoang ke ho se leka-lekane pakeng tsa li-free radical le li-antioxidants 'meleng, e amahanngoa le mafu a mangata, ho kenyeletsoa kankere, lefu la pelo le methapo ea mali le mathata a methapo ea kutlo. Ka ho tlosa li-free radical le ho fokotsa tšenyo ea oxidative, 1,4-dihydronicotinamide riboside e ka fana ka melemo e meng ea bophelo bo botle ho feta karolo ea eona e le selelekela sa NAD+.
Tšobotsi
(1) Bohloeki bo phahameng: 1,4-dihydronicotinamide riboside e ka fumana dihlahiswa tse hlwekileng haholo ka mekgwa e hlwekileng ya tlhahiso. Bohloeki bo phahameng bo bolela ho fumaneha ha di-bioavailability tse betere le dikarabelo tse fokolang tse mpe.
(2) Polokeho: 1,4-dihydronicotinamide riboside ke sehlahisoa sa tlhaho se pakiloeng hore se bolokehile bakeng sa 'mele oa motho.
(3) Botsitso: 1,4-dihydronicotinamide riboside e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng a tikoloho le a polokelo.
Likopo
1,4-Dihydronicotinamide ke mofuta o fokotsehileng wa nicotinamide riboside. E ka ba teng ka mefuta e nang le oxidized le e fokotsehileng mme ke selelekela sa NAD e sa tswa sibollwa (nicotinamide adenine dinucleotide), e fumanehang e le tlatsetso, mme NRH e le selelekela sa NAD+ se matla le se potlakileng ho feta NR.
