Moetsi oa phofo ea Agomelatine Nomoro ea CAS: 138112-76-2 Bohloeki ba 99% bonyane bakeng sa metsoako ea tlatsetso
Video ea Sehlahisoa
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | Agomelatin |
| Lebitso le leng | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Nomoro ea CAS | 138112-76-2 |
| Foromo ea limolek'hule | C15H17NO2 |
| Boima ba limolek'hule | 243.3082 |
| Bohloeki | 99.0% |
| Ponahalo | Phofo e tšoeu |
| Ho paka | 1kg/mokotlana 25kg/moropa |
| Kopo | Lihlahisoa tsa bophelo bo botle |
Selelekela sa sehlahisoa
Agomelatine e qalile ho qalisoa Europe ka 2009 'me joale e amohetsoe hore e sebelisoe linaheng tse fetang 70. Ho fapana le meriana ea ho loantša khatello ea maikutlo ea setso, agomelatine e sebetsa ka ho shebana le melatonin le li-receptor tsa serotonin bokong. Ka ho sebetsa e le agonist ho li-receptor tsa melatonin, agomelatine e thusa ho lokisa mekhoa ea ho robala e sitisitsoeng eo hangata e amanang le khatello ea maikutlo. Mokhoa ona ha o thuse feela ho ntlafatsa boleng ba boroko empa hape o thusa ho tsosolosa meroalo ea tlhaho ea circadian. Ho phaella moo, agomelatine e sebetsa e le mohanyetsi ho li-receptor tse itseng tsa serotonin (li-receptor tsa 5-HT2C). Ketso ena e ikhethang e habeli e ntlafatsa ka tsela e sa tobang ho fumaneha ha serotonin bokong, e leng neurotransmitter e ikarabellang bakeng sa ho laola maikutlo. Ka ho laola maemo a serotonin, agomelatine e ka sebetsa e le moriana o sebetsang oa ho loantša khatello ea maikutlo, e imolla matšoao a kang ho hlonama, ho lahleheloa ke thahasello, maikutlo a molato kapa ho hloka thuso. Ho feta moo, agomelatine e ka fana ka melemo e meng. Lipatlisiso li bontša hore e ka thusa ho ntlafatsa ts'ebetso ea kelello. Lipatlisiso li bontša bokhoni ba eona ba ho ntlafatsa mohopolo, tlhokomelo le ts'ebetso ea phethahatso, e leng se etsang hore e be sebaka se thabisang bakeng sa lipatlisiso tsa nakong e tlang.
Tšobotsi
(1) Bohloeki bo phahameng: Agomelatine e ka fumana dihlahiswa tse hlwekileng haholo ka mekgwa ya tlhahiso ya ho hlwekisa. Bohloeki bo phahameng bo bolela ho fumaneha ha dihlahiswa hantle le dikarabelo tse fokolang tse mpe.
(2) Polokeho: Polokeho e phahameng, dikarabelo tse fokolang tse mpe.
(3) Botsitso: Agomelatine e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng a tikoloho le maemo a polokelo.
Likopo
Agomelatine ke moriana o thibelang ho tepella maikutlo le mohanyetsi oa melatonin. E fokotsa matšoao a khatello ea maikutlo ka ho laola li-receptor tsa melatonin MT1 (e fokotsa matšoao a alamo ea cortical) le li-receptor tsa MT2 (mokhoa oa boroko oa circadian) le maemo a serotonin. E nooa bosiu, e etsisa morethetho oa tlhaho oa ho lokolloa ha melatonin 'me e ka ntlafatsa boleng ba boroko haholo. Mokhoa oa eona oa tšebetso o phunyeletsa tsamaiso ea setso ea monoamine transmitter. E kenya tšebetsong li-receptor tsa melatonin MT1 le MT2 'me e hanyetsa li-receptor tsa 5-HT2C. E ntlafatsa boleng ba boroko, e tsosolosa morethetho oa baeloji, 'me e na le phello ea ho thibela ho tepella maikutlo; har'a tsona, ka ho hanyetsa li-receptor tsa 5-HT2C holim'a lera la postsynaptic, e ka eketsa ho lokolloa ha DA le NE karolong ea prefrontal cortex, e leng se etsang hore motho a se ke a tepella maikutlo. Ha MT agonism le mokhoa oa ho thibela ho tšoaroa ke lefu la 5-HT2C li kopana, phello e ikhethang ea tšebelisano-'moho e ka hlahisoa, e khothalletsa ho lokolloa ha DA le NE tse ngata sebakeng sa boko ba PFC, e leng se matlafatsang le ho feta phello ea ho thibela ho tšoaroa ke lefu la migraine. Ho phaella moo, agomelatine e ka kgothaletsa ho lokollwa ha neurotrophic factor e tswang bokong ho PFC mme ya thibela ho lokollwa ha glutamate e bakwang ke kgatello sebakeng sa boko sa amygdala.
