Moetsi oa phofo ea Agomelatine CAS No.: 138112-76-2 99% bohloeki min.bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | Agomelatine |
| Lebitso le leng | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Nomoro ea CAS. | 138112-76-2 |
| Mokhoa oa limolek'hule | C15H17NO2 |
| Boima ba molek'hule | 243.3082 |
| Bohloeki | 99.0% |
| Ponahalo | Phofo e tšoeu |
| Ho paka | 1kg/ mokotla 25kg / moropa |
| Kopo | Health sehlahisoa lihlahisoa tse tala |
Kenyelletso ea sehlahisoa
Agomelatine ke mofuta o mocha oa antidepressant.Mokhoa oa eona oa ts'ebetso o phunyeletsa ka mokhoa oa setso oa ho fetisa monoamine.E kenya tšebetsong li-receptor tsa melatonin, MT1 le MT2, 'me e hanyetsa li-receptor tsa 5-HT2C.E ka ntlafatsa boleng ba boroko le ho khutlisetsa morethetho oa biological ha o ntse o e-na le phello ea antidepressant;har'a bona, ka ho hanyetsa mokelikeli oa 5-HT2C oa membrane ea postsynaptic, e ka eketsa ho lokolloa ha DA le NE ka har'a prefrontal cortex le ho bapala karolo ea ho tepella maikutlo.Ha MT agonism le 5-HT2C receptor antagonism e le teng ka nako e le 'ngoe, phello e ikhethang ea synergistic e ka hlahisoa ho khothalletsa ho lokolloa ha DA le NE ho feta sebakeng sa boko ba PFC, ho matlafatsa ka ho eketsehileng phello ea ho tepella maikutlo.Ho phaella moo, agomelatine e ka boela ea khothalletsa ho lokolloa ha boko bo entsoeng ke neurotrophic factor PFC le ho thibela ho lokolloa ha glutamate ka lebaka la khatello ea kelello sebakeng sa boko ba amygdala.
Sebopeho
(1) Taolo e 'meli: Ha e khone ho laola feela ho lokolloa ha melatonin, empa hape e laola ho lokolloa ha 5-hydroxytryptamine le norepinephrine, kahoo e phetha karolo ea ho laola maikutlo, boroko, bohloko joalo-joalo.
(2) Ho ntlafala ha boroko: Agomelatine ke e ka ntlafatsang ho hlobaela ntle le ho baka ho otsela kapa ho akheha.
(3) Ntlafatsa ts'ebetso ea kelello: Agomelatine e ka ntlafatsa ts'ebetso ea kelello ka ho ntlafatsa neuroplasticity ho hippocampus.
(4) Tšireletseho e phahameng: Ha e bapisoa le li-antidepressants tse ling, sethethefatsi se na le litla-morao tse batlang li fokola ha se phekola ho tepella maikutlong, 'me se ke ke sa ama ts'ebetso ea thobalano le boima ba' mele.
Lisebelisoa
Agomelatine ke ea antidepressant eo hape e leng mohanyetsi oa melatonin.E fokotsa matšoao a tepeletseng ka ho fetola maemo a melatonin MT1 receptors (ho fokotsa matšoao a alamo ea cortical) le li-receptor tsa MT2 (ho ea ho circadian rhythms of sleep) le serotonin.Ho nkoa bosiu ho etsisa morethetho oa tlhaho oa ho lokolloa ha melatonin, ho ka ntlafatsa boleng ba boroko haholo.
