7,8-Dihydroxyflavone ke eng, 'me Ke Hobane'ng ha U Lokela ho Hlokomela?

7,8-Dihydroxyflavone (7,8-DHF)ke flavonoid ea tlhaho ea tlhaho, motsoako oa polyphenolic o fumanoang limela tse fapaneng. Li-Flavonoids li tsebahala ka thepa ea tsona ea antioxidant 'me li bapala karolo ea bohlokoa mekhoeng ea ts'ireletso ea limela. 7,8-Dihydroxyflavone e fumaneha haholo limela tse kang Godmania aesculifolia le Tridax procumbens.

7,8-Dihydroxyflavone e fapane le li-flavonoids tse ling ka bokhoni ba eona ba ho etsisa mosebetsi oa boko bo entsoeng ke neurotrophic factor (BDNF). BDNF ke protheine e ts'ehetsang ho phela, nts'etsopele le ts'ebetso ea methapo ea kutlo bokong. E bapala karolo ea bohlokoa ho neuroplasticity, bokhoni ba boko ba ho itlhophisa bocha ka ho theha likhokahano tse ncha tsa methapo. Thepa ena ea 7,8-DHF e bula mekhoa e mengata ea lipatlisiso, haholo-holo lefapheng la mahlale a methapo.

Mokhoa oa ts'ebetso

Mokhoa o ka sehloohong oo 7,8-Dihydroxyflavone e hlahisang liphello tsa oona ke ts'ebetsong ea TrkB (tropomyosin receptor kinase B) receptor. TrkB ke receptor e phahameng ea kamano bakeng sa BDNF. Ha 7,8-Dihydroxyflavone e tlama ho TrkB, e etsa hore ho be le letoto la litsela tsa lipontšo tsa intracellular tse khothalletsang ho phela ha neuronal, kholo le phapang.

Liphuputso tsa pele ho kliniki li bontšitse hore 7,8-dihydroxyflavone e ka etsisa BDNF (brain-derived neurotrophic factor) le ho eketsa ponahalo ea eona le maemo a hippocampus. Mehlala ea liphoofolo, e na le monyetla oa ho phekola mafu a 'maloa a methapo ea kutlo kapa mafu, e leng stroke, khatello ea maikutlo le lefu la Parkinson. Lithutong tse peli tse fapaneng, 7,8-dihydroxyflavone e bontšitse bioavailability ea bohlokoa ea molomo mme e fumanoe e tšela mokoallo oa mali bokong (BBB). Hobane e sebetsa tseleng ea ponts'o ea nitric oxide le e kentsoeng TrkB receptor (tropomyosin receptor kinase B)

The neurotrophic factor BDNF haholo-holo e fetisetsa lipontšo ka ho tlama li-receptor tse itseng, kahoo e ama mekhoa ea 'mele ea methapo ea kutlo. Le hoja 7,8-DHF e ka etsisa phello ea neurotrophic factor BDNF, senotlolo se lutse mochineng oa eona oa ho sebelisana le BDNF receptor. Liphuputso li bontšitse hore 7,8-DHF e ka tlama ho BDNF receptor TrkB le ho kenya tšebetsong litsela tsa matšoao a tlase.

Ka ho khetheha, ha 7,8-DHF e tlama ho TrkB, e baka letoto la liketsahalo tsa ho fetisetsa lipontšo tsa intracellular. Sena se kenyelletsa ts'ebetso ea protheine kinases joalo ka PI3K/Akt le MAPK/ERK litsela. Ho kenya tšebetsong litsela tsena ho bohlokoa bakeng sa ho khothaletsa bophelo ba neuronal, kholo, le polasetiki ea synaptic. Ka ho etsisa ts'ebetso ea litsela tsena ka BDNF, 7,8-DHF e thusa ho ntlafatsa ho ikamahanya le maemo a neuronal le ho hanyetsa khatello ea kelello e ka ntle.

7,8-DHF e boetse e laola liphatsa tsa lefutso ka har'a methapo ea kutlo. E ka ama ho ngoloa ha liphatsa tsa lefutso tse amanang le neurodevelopment, neuroprotection le synapse formation, kahoo e etsisa liphello tsa BDNF boemong ba molek'hule. Ho feto-fetoha ha liphatsa tsa lefutso ho tšehetsa karolo ea 7,8-DHF ho khothalletsa bophelo bo botle ba methapo.

7,8-Dihydroxyflavone (7,8-DHF) ke monophenolic flavonoid e nang le liphello tse ngata. E sebetsa e le agonist bakeng sa neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) mme e sireletsa li-neuron tse hlahisang TrkB ho tloha ho apoptosis. Brain-derived neurotrophic factor (BDNF) ke protheine e nang le litlamorao tsa neurotrophic e bohlokoa bakeng sa ho theha boko, ho ithuta le mohopolo.

• Neuroprotection: 7,8-DHF e sireletsa methapo ea kutlo mefuteng ea liphoofolo tsa lefu la Parkinson, e tšehetsa thuto ea maikutlo ho litoeba le ho khutlisa khaello ea mohopolo mefuteng ea litoeba tsa lefu la Alzheimer's, hape e ka ntlafatsa ts'ebetso ea mesifa le ho lelefatsa nako ea ho phela ha huntingtin ho mefuta ea liphoofolo tse kulang. BDNF e ka ntlafatsa ho phela ha neuroplasticity le neuron, ea thusa boko ho hlahisa likhokahano tse ncha tsa methapo, ho lokisa lisele tsa boko tse hlolehang, le ho sireletsa lisele tse phetseng hantle tsa boko. E bohlokoa bakeng sa ho theoa ha boko, ho ithuta le mohopolo, 'me e ka sireletsa boko bofokoling bo amanang le lilemo. Fokotsa bokhoni ba kelello le ho itšireletsa khahlanong le mafu a neurodegenerative joalo ka lefu la Alzheimer le lefu la Parkinson.

• E laola ho phela ha methapo ea kutlo: 7,8-DHF e ka tlama TrkB le ho kenya tšebetsong litsela tsa matšoao a tlase, joalo ka PI3K/Akt le MAPK/ERK litsela. Ts'ebetso ea litsela tsena e bohlokoa bakeng sa ho khothaletsa pholoho ea neuronal, kholo le polasetiki ea synaptic. bohlokoa. BDNF e boetse e le ntho ea neurotrophic e ka kenyang litsela tsa lipontšo tsa intracellular ka ho tlama li-receptor tsa TrkB le ho khothalletsa ho phela le ho hōla ha methapo ea kutlo.

• Ho khothalletsa polasetiki ea synaptic: 7,8-DHF e ka khothalletsa ho thehoa le ho matlafatsa li-synapse ka ho kenya li-receptor tsa TrkB, ka hona ho ntlafatsa katleho ea phetisetso ea synaptic. BDNF e boetse e nahanoa hore e khothalletsa ho thehoa le ho matlafatsa li-synapses, kahoo e eketsa katleho ea phetisetso ea synaptic 'me kahoo e matlafatsa bokhoni ba ho ithuta le ho hopola.

• Liphello tsa ho ithuta le mohopolo: 7,8-DHF e ka ntlafatsa bokhoni ba ho ithuta le ho hopola litoeba, tse ka amanang le liphello tsa eona ho pholoho ea neuronal le synaptic plasticity. BDNF e boetse e phetha karolo ea bohlokoa litabeng tsa ho ithuta le ho hopola mohopolo ka ho khothalletsa ho phela ha methapo ea kutlo le ho thehoa ha li-synapses, kahoo ho ntlafatsa bokhoni ba ho ithuta le ho hopola.

• E fetola maikutlo: 7,8-DHF e na le liphello tse fetolang maikutlo, tse ka 'nang tsa amana le liphello tsa eona ho pholoho ea neuronal le synaptic plasticity. BDNF e boetse e nahanoa hore e phetha karolo ea ho laola maikutlo ka ho laola ho phela ha li-neuron le ho thehoa ha li-synapse, kahoo li ama polelo ea maikutlo.

Ka kakaretso, 7,8-DHF le BDNF li na le mekhoa e ts'oanang ea ts'ebetso ea ts'ebetso ea neuroprotection, ho laola ho pholoha ha neuronal, ho khothalletsa polasetiki ea synaptic, ho ama thuto le mohopolo, le ho laola maikutlo.

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka boleng bo holimo le bohloeki ba 7,8-Dihydroxyflavone.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle. 7,8-Dihydroxyflavone ea rona e lekoa ka matla bakeng sa bohloeki le matla, ho netefatsa hore o fumana tlatsetso ea boleng bo holimo eo u ka e tšepang. Hore na o batla ho ts'ehetsa bophelo bo botle ba lisele, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, 7,8-Dihydroxyflavone ea rona ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 'me e susumetsoa ke thekenoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e hlahisitse lihlahisoa tse ngata tsa tlholisano mme e fetohile tlatsetso e ncha ea mahlale a bophelo, ho kopanya tloaelo le k'hamphani ea lits'ebeletso tsa tlhahiso.

Ntle le moo, Suzhou Myland Pharm le eona ke moetsi ea ngolisitsoeng ke FDA. Lisebelisoa tsa R&D tsa k'hamphani, lisebelisoa tsa tlhahiso, le lisebelisoa tsa tlhahlobo ke tsa sejoale-joale ebile li na le mesebetsi e mengata, 'me li ka hlahisa lik'hemik'hale ho tloha ho limiligrama ho isa ho lithane ka tekanyo,' me li lumellana le litekanyetso tsa ISO 9001 le litlhaloso tsa tlhahiso ea GMP.