7,8-Dihydroxyflavone ke eng, hona ke hobane'ng ha u lokela ho tsotella?

7,8-Dihydroxyflavone (7,8-DHF)ke flavonoid e hlahang ka tlhaho, motsoako oa polyphenolic o fumanoang limela tse fapaneng. Li-flavonoid li tsebahala ka thepa ea tsona ea antioxidant 'me li bapala karolo ea bohlokoa mekhoeng ea ho itšireletsa limela. 7,8-Dihydroxyflavone e fumanoa haholo-holo limela tse kang Godmania aesculifolia le Tridax procumbens.

7,8-Dihydroxyflavone e fapane le di-flavonoid tse ding ka bokgoni ba yona ba ho etsisa mosebetsi wa neurotrophic factor e tswang bokong (BDNF). BDNF ke protheine e tshehetsang ho phela, ntshetsopele le tshebetso ya di-neuron bokong. E bapala karolo ya bohlokwa ho neuroplasticity, bokgoni ba boko ba ho itlhophisa botjha ka ho theha dikgokelo tse ntjha tsa methapo. Thepa ena ya 7,8-DHF e bula menyetla e mengata ya dipatlisiso, haholoholo lefapheng la neuroscience.

Mokhoa oa ketso

Mokhoa o ka sehloohong oo 7,8-Dihydroxyflavone e sebelisang litlamorao tsa eona ka oona ke ho kenya tšebetsong ha receptor ea TrkB (tropomyosin receptor kinase B). TrkB ke receptor e nang le kamano e phahameng bakeng sa BDNF. Ha 7,8-Dihydroxyflavone e ikamahanya le TrkB, e qala letoto la litsela tsa lipontšo tsa ka hare ho sele tse khothalletsang ho phela ha methapo ea kutlo, kholo le phapang.

Lithuto tsa pele ho kliniki li bontšitse hore 7,8-dihydroxyflavone e ka etsisa BDNF (neurotrophic factor e nkiloeng bokong) 'me ea eketsa tlhahiso le maemo a eona ka har'a hippocampus. Mehlaleng ea liphoofolo, e na le bokhoni ba ho phekola mafu a 'maloa a methapo ea kutlo kapa mathata, e leng stroke, khatello ea maikutlo, le lefu la Parkinson. Lithutong tse peli tse fapaneng, 7,8-dihydroxyflavone e bontšitse ho fumaneha ha bohlokoa ha molomo 'me e fumanoe e tšela mokoallo oa mali le boko (BBB). Hobane e sebetsa tseleng ea lipontšo tsa nitric oxide le ho kenya tšebetsong receptor ea TrkB (tropomyosin receptor kinase B)

Ntho ea neurotrophic BDNF e fetisa matšoao haholo-holo ka ho tlama ho li-receptor tse itseng, ka hona e ama lits'ebetso tsa 'mele tsa li-neuron. Leha 7,8-DHF e ka etsisa phello ea ntho ea neurotrophic BDNF, senotlolo se ho mokhoa oa eona oa ho sebelisana le receptor ea BDNF. Lithuto li bontšitse hore 7,8-DHF e ka tlama ho receptor ea BDNF TrkB le ho kenya tšebetsong litsela tsa lipontšo tse theohelang.

Haholo-holo, ha 7,8-DHF e tlamahana le TrkB, e baka letoto la liketsahalo tsa phetisetso ea lets'oao ka hare ho sele. Sena se kenyelletsa ho kengoa tšebetsong ha li-kinase tsa protheine tse kang litsela tsa PI3K/Akt le MAPK/ERK. Ho kengoa tšebetsong ha litsela tsena ho bohlokoa bakeng sa ho khothaletsa ho phela ha methapo ea kutlo, kholo le ho rarahana ha synaptic. Ka ho etsisa ho kengoa tšebetsong ha litsela tsena ke BDNF, 7,8-DHF e thusa ho ntlafatsa ho ikamahanya le maemo ha methapo ea kutlo le ho hanyetsa khatello ea maikutlo ea kantle.

7,8-DHF e boetse e laola tlhahiso ea liphatsa tsa lefutso ka har'a li-neuron. E ka ama phetolelo ea liphatsa tsa lefutso tse amanang le nts'etsopele ea methapo ea kutlo, ts'ireletso ea methapo ea kutlo le ho thehoa ha synapse, ka hona e etsisa liphello tsa BDNF boemong ba limolek'hule. Phetoho ena ea tlhahiso ea liphatsa tsa lefutso e tšehetsa karolo ea 7,8-DHF ho ntšetseng pele bophelo bo botle ba methapo ea kutlo.

7,8-Dihydroxyflavone (7,8-DHF) ke flavonoid e nang le ditlamorao tse ngata. E sebetsa e le agonist bakeng sa neurotrophic tyrosine kinase receptor TrkB (Kd=320nM) mme e sireletsa di-neuron tse hlahisang TrkB ho apoptosis. Brain-derived neurotrophic factor (BDNF) ke protheine e nang le ditlamorao tsa neurotrophic tse bohlokwa bakeng sa ho thehwa ha boko, ho ithuta le ho hopola.

• Tšireletso ea methapo ea kutlo: 7,8-DHF e sireletsa methapo ea kutlo mehlaleng ea liphoofolo tsa lefu la Parkinson, e tšehetsa ho ithuta maikutlong litoebeng 'me e fokotsa likhaello tsa mohopolo mehlaleng ea litoeba tsa lefu la Alzheimer, 'me e ka boela ea ntlafatsa ts'ebetso ea methapo ea kutlo le ho lelefatsa nako ea ho phela ha liphoofolo tse kulang. BDNF e ka ntlafatsa neuroplasticity le ho phela ha methapo ea kutlo, ea thusa boko ho hlahisa likhokahano tse ncha tsa methapo ea kutlo, ea lokisa lisele tsa boko tse hlolehang, le ho sireletsa lisele tse phetseng hantle tsa boko. E bohlokoa bakeng sa ho thehoa ha boko, ho ithuta le ho hopola, 'me e ka sireletsa boko ho tsoa bofokoling ba kelello bo amanang le botsofali. E fokotseha bokhoning ba kelello le ho sireletsa khahlanong le mafu a methapo a kang lefu la Alzheimer le lefu la Parkinson.

• E laola ho phela ha methapo ea kutlo: 7,8-DHF e ka tlama ho TrkB le ho kenya tšebetsong litsela tsa ho fetisa melaetsa tse theohelang tlase, joalo ka litsela tsa PI3K/Akt le MAPK/ERK. Ho kenya tšebetsong litsela tsena ho bohlokoa bakeng sa ho khothaletsa ho phela ha methapo ea kutlo, kholo le ho rarahana ha synaptic. BDNF hape ke ntlha ea neurotrophic e ka kenyang tšebetsong litsela tsa ho fetisa melaetsa tse ka hare ho sele ka ho tlama ho li-receptor tsa TrkB le ho khothaletsa ho phela le ho hola ha li-neuron.

• Ho kgothaletsa ho ba le plasticity ya synapse: 7,8-DHF e ka kgothaletsa ho thehwa le ho matlafatswa ha di-synapse ka ho kenya tshebetsong di-receptor tsa TrkB, ka hona e ntlafatsa bokgoni ba phetiso ya synapse. BDNF e boetse e nahannwa hore e kgothaletsa ho thehwa le ho matlafatswa ha di-synapse, ka hona e eketsa bokgoni ba phetiso ya synapse mme ka hona e ntlafatsa bokgoni ba ho ithuta le ho hopola.

• Litlamorao ho ithuteng le mohopolong: 7,8-DHF e ka ntlafatsa bokhoni ba ho ithuta le ba ho hopola litoeba, e leng se ka amanang le litlamorao tsa eona ho pholoheng ha methapo ea kutlo le ho rarahana ha synapse. BDNF e boetse e bapala karolo ea bohlokoa lits'ebetsong tsa ho ithuta le tsa ho hopola ka ho khothaletsa ho pholoha ha li-neuron le ho thehoa ha li-synapses, ka hona e ntlafatsa bokhoni ba ho ithuta le ba ho hopola.

• E fetola maikutlo: 7,8-DHF e na le litlamorao tsa ho fetola maikutlo, tse ka amanang le litlamorao tsa eona ho pholoheng ha methapo ea kutlo le ho rarahana ha synapse. BDNF e boetse e nahanoa hore e bapala karolo taolong ea maikutlo ka ho laola ho pholoha ha methapo ea kutlo le ho thehoa ha li-synapse, ka hona e ama polelo ea maikutlo.

Ka bokhutšoanyane, 7,8-DHF le BDNF li na le mekhoa e tšoanang ea ts'ebetso ts'ireletsong ea methapo ea kutlo, e laolang ho phela ha methapo ea kutlo, e khothalletsa ho rarahana ha synaptic, e amang ho ithuta le ho hopola, le ho laola maikutlo.

Suzhou Myland Pharm & Nutrition Inc. ke moetsi ea ngolisitsoeng ke FDA ea fanang ka boleng bo holimo le bo hloekileng ba 7,8-Dihydroxyflavone.

Ho Suzhou Myland Pharm re ikemiselitse ho fana ka lihlahisoa tsa boleng bo holimo ka litheko tse ntle ka ho fetisisa. 7,8-Dihydroxyflavone ea rona e lekoa ka hloko bakeng sa bohloeki le matla, ho netefatsa hore u fumana tlatsetso ea boleng bo holimo eo u ka e tšepang. Hore na u batla ho tšehetsa bophelo bo botle ba lisele, ho matlafatsa sesole sa hau sa 'mele kapa ho ntlafatsa bophelo bo botle ka kakaretso, 7,8-Dihydroxyflavone ea rona ke khetho e phethahetseng.

Ka boiphihlelo ba lilemo tse 30 le ho khannoa ke theknoloji e phahameng le maano a R&D a ntlafalitsoeng haholo, Suzhou Myland Pharm e ntlafalitse mefuta e fapaneng ea lihlahisoa tse hlōlisanang 'me e fetohile khamphani e ncha ea tlatsetso ea mahlale a bophelo, tlhahiso ea lintho tse ikhethileng le lits'ebeletso tsa tlhahiso.

Ho phaella moo, Suzhou Myland Pharm le yona ke moetsi ya ngodisitsweng ke FDA. Mehlodi ya R&D ya khamphani, dibaka tsa tlhahiso, le disebediswa tsa tlhahlobo ke tsa sejwalejwale mme di sebetsa ka bongata, mme di ka hlahisa dikhemikhale ho tloha ho dimiligrama ho isa ho ditone ka boholo, mme di latela maemo a ISO 9001 le ditlhaloso tsa tlhahiso GMP.