Nomoro ea CAS ea SLU-PP-332: 303760-60-3
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | SLU-PP-332 |
| Lebitso le leng | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide；4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide； |
| Nomoro ea CAS | 303760-60-3 |
| Foromo ea limolek'hule | C18H14N2O2 |
| Boima ba limolek'hule | 290.32 |
| Bohloeki | 98% |
| Ponahalo | Phofo e tšoeu kapa e sa soeufalang |
| Ho paka | 1kg/mokotla, 25kg/barele |
| Kopo | Lisebelisoa tse Tala tsa Tlatsetso ea Lijo |
Selelekela sa sehlahisoa
SLU-PP-332 ke motsoako o mocha o monyane oa molek'hule o sebetsang e le agonist ea perifollicle estrogen receptor (ERR), haholo-holo e shebaneng le ERRα, ERRβ, le ERRγ, ka phello e matla ka ho fetisisa ea ts'ebetso ho ERRα (EC₅₀=98 nM). Motsoako ona o kenya tšebetsong tsela ea lipontšo tsa ERR ka ho etsisa mekhoa ea taolo ea metabolism ea boikoetliso, ka hona o fetola metabolism ea matla, ts'ebetso ea mitochondrial le mamello ea mesifa.
Tšobotsi
(1) Mokhoa oa ts'ebetso: ho kenya tšebetsong ERRα/β/γ, ho eketsa oxidation ea fatty acid (FAO) le liphatsa tsa lefutso tse amanang le ho hema ha mitochondrial, ho khothaletsa ho senyeha ha mafura bakeng sa phepelo ea matla, ho fokotsa ho bokellana ha mafura, ho ntlafatsa ts'ebetso ea mitochondrial ea mesifa ea masapo, ho ntlafatsa bokhoni ba oxidation le mamello, tse tšoanang le phello ea koetliso ea aerobic.
(2) Mosebetsi oa 'mele: a) Litlamorao tsa mohlala oa liphoofolo: Litoeba tse nonneng: kamora matsatsi a 28 a meriana, boima ba 'mele bo fokotsehile ka 12%, 'me mafura a sebete, k'holeseterole le triglycerides li fokotsehile haholo; litoeba tse tloaelehileng: nako ea ho matha e eketsehile ka 70%, sebaka se eketsehile ka 45%, ntle le ho ama takatso ea lijo kapa ho ithaopela ho tsamaea. b) Polokeho: ha ho na litla-morao tse tebileng tse ileng tsa bonoa lithutong tsa pele ho tleliniki.
(3) Litšobotsi tsa 'mele le tsa lik'hemik'hale: e tšoeu ho isa ho e tšoeu e tiileng, e qhibilihang ka har'a DMSO (75 mg/mL) le ethanol, e sa qhibiliheng metsing; e lokela ho bolokoa lefifing.
Likopo
SLU-PP-332 e fihlella tahlehelo ea mafura le taolo ea tsoekere maling ka ho khothaletsa ho oxidation ea mafura le ho ntlafatsa kutloisiso ea insulin; e ntlafatsa lefu la sebete le se nang joala (NAFLD), e fokotsa mafura a sebete; e fana ka tšehetso ea metabolism bakeng sa batho ba sa khoneng ho ikoetlisa, ho boloka mesifa le ts'ebetso ea eona; e fokotsa tahlehelo ea mesifa nakong ea ts'ebetso ea tahlehelo ea mafura; 'me e na le menyetla e meholo libakeng tsa tahlehelo ea mafura, ntlafatso ea mamello le ntlafatso ea metabolism.
