1,4-DihydronicotinaMide Riboside phofo moetsi CAS No.: 19132-12-8 98% bohloeki min. bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | 1,4-DihydronicotinaMide Riboside |
| Lebitso le leng | 1,4-DIHYDRONICOTINAMIDE RIBOSIDE1-[(3R,4S,5R) -3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl] -1,4-dihydropyridine-3-carboxamideSCHEMBL188493711-[(3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-4H-PYRIDINE-3-CARBOXAMIDE |
| Nomoro ea CAS. | 19132-12-8 |
| Mokhoa oa limolek'hule | C11H16N2O5 |
| Boima ba molek'hule | 256.26 |
| Bohloeki | 98% |
| Ponahalo | Phofo e tšoeu |
| Ho paka | 1kg / mokotla; 25kg / moropa |
| Kopo | Lijo tse tlatsetsang lisebelisoa tse tala |
Kenyelletso ea sehlahisoa
1,4-dihydronicotinamide riboside, e tsejoang hape e le NRH.Mofuta o fokotsehileng oa NRH ke selelekela se matla sa NAD+ se thusang ho tlatsa maemo a sona seleng.
Pele ho tsohle, ho bohlokoa ho utloisisa karolo ea NAD + 'meleng. NAD+ ke coenzyme e amehang lits'ebetsong tse ngata tsa cellular, ho kenyelletsa metabolism ea matla, tokiso ea DNA, le polelo ea lefutso. Ha re ntse re tsofala, maemo a rona a NAD + a fokotseha, a amehang ts'ebetsong ea botsofali le mafu a amanang le lilemo. Sena se lebisitse thahasellong e ntseng e hola ea ho tsebahatsa limolek'hule tse ka nyollang maemo a NAD+ 'meleng, mme 1,4-dihydronicotinamide riboside ke e 'ngoe ea molek'hule e joalo.
1,4-dihydronicotinamide riboside ke selelekela sa NAD+ se matla, 'me lipatlisiso li bonts'itse hore e ka phahamisa maemo a NAD+ ka katleho liseleng. Sena se lebisitse ho khakanyo ea hore tlatsetso ea 1,4-dihydronicotinamide riboside e ka ba le monyetla oa kalafo maemong a fapaneng a bophelo bo botle, ho kenyeletsoa mathata a metabolic, mafu a neurodegenerative, le ho fokotseha ho amanang le botsofali.
Ebile, ho na le bopaki ba ho fana ka maikutlo a hore 1,4-dihydronicotinamide riboside e kanna ea sebetsa le ho feta molek'hule ea motsoali, nicotinamide riboside, maemong a ntseng a eketseha a NAD +. Sena ke hobane 1,4-dihydronicotinamide riboside ke se fokotsang matla ho feta, ho bolelang hore ho molemo ho fana ka lielektrone tseleng ea motsoako oa NAD+. Ka lebaka leo, e na le monyetla oa ho hlahisa tlhahiso ea cellular ea NAD + ka katleho.
Ntle le karolo ea eona ho NAD+ biosynthesis, 1,4-dihydronicotinamide riboside e boetse e na le thepa ea antioxidant. Khatello ea oxidative, e bakoang ke ho se leka-lekane lipakeng tsa li-radicals tsa mahala le li-antioxidants 'meleng, e ameha mafung a mangata, ho kenyelletsa mofetše, lefu la pelo le mafu a neurodegenerative. Ka ho hlakola li-radicals tsa mahala le ho fokotsa tšenyo ea oxidative, 1,4-dihydronicotinamide riboside e ka fana ka melemo e meng ea bophelo bo botle ho feta karolo ea eona e le selelekela sa NAD+.
Sebopeho
(1) Bohloeki bo phahameng: 1,4-dihydronicotinamide riboside e ka fumana lihlahisoa tse phahameng tsa bohloeki ka mekhoa e hloekisitsoeng ea tlhahiso. Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: 1,4-dihydronicotinamide riboside ke sehlahisoa sa tlhaho se bontšitsoeng se sireletsehile bakeng sa 'mele oa motho.
(3) Botsitso: 1,4-dihydronicotinamide riboside e na le botsitso bo botle 'me e ka boloka ts'ebetso ea eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
Lisebelisoa
1,4-Dihydronicotinamide ke mofuta o fokolitsoeng oa nicotinamide riboside. E ka ba teng ka mefuta e 'meli ea oxidized le e fokotsehileng' me ke selelekela sa NAD e sa tsoa sibolloa (nicotinamide adenine dinucleotide), e fumanehang e le tlatsetso, 'me NRH e le selelekela sa NAD+ se matla le se potlakileng ho feta NR.
