Moetsi oa phofo ea N-Boc-O-Benzyl-D-serine Nomoro ea CAS:47173-80-8 Bohloeki ba 98% bonyane bakeng sa Li-Intermediate
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | N-Boc-O-Benzyl-D-serine |
| Lebitso le leng | N-Boc-O-benzyl-D-serine; Boc-O-benzyl-D-serine; O-Benzyl-N-(tert-butoxycarbonyl)-D-serine; Boc-(R)-2-amino-3-benzyloxypropionic acid; Boc-D-Ser(Bzl)-OH;Nat.-Boc-O-benzyl-D-serine; N-tert-butyloxycarbonyl-O-benzyl-D-serine; Nalpha-t-butoxycarbonyl-O-benzyl-D-serine; |
| Nomoro ea CAS | 47173-80-8 |
| Foromo ea limolek'hule | C15H21NO5 |
| Boima ba limolek'hule | 295.33 |
| Bohloeki | 98% |
| Ho paka | 1kg/mokotla; 25kg/moropa |
| Kopo | Batho ba mahareng |
Selelekela sa sehlahisoa
N-Boc-O-Benzyl-D-serine ke motsoako o fumaneng tlhokomelo e kholo lefapheng la k'hemistri ea lintho tse phelang le lipatlisiso tsa meriana. Motsoako ona, o tsejoang hape e le Boc-D-serine, ke motsoako oa amino acid D-serine 'me o sebelisoa haholo ho kopanyeng meriana e fapaneng le limolek'hule tse sebetsang. N-Boc-O-Benzyl-D-serine ke phofo ea kristale e tšoeu ho isa ho e tšoeu e qhibilihang hanyane ka metsing 'me e qhibilihang ka har'a li-solvents tsa lintho tse phelang tse kang methanol le ethanol. Ke motsoako oa D-serine, e leng amino acid e seng ea protheine e bapalang karolo ea bohlokoa tsamaisong ea methapo e bohareng e le co-agonist ea N-methyl-D-aspartate (NMDA) receptor. Lihlopha tsa N-Boc (tert-butoxycarbonyl) le O-Benzyl tse motsoakong li sebetsa e le lihlopha tse sireletsang, tse lumellang ho sebelisoa ka mokhoa o ikhethileng ha amino acid nakong ea tlhahiso ea lik'hemik'hale. N-Boc-O-Benzyl-D-serine e sebelisoa haholo-holo e le motheo oa tlhahiso ea li-peptide le li-peptidomimetics. Li-peptide ke liketane tse khutšoane tsa li-amino acid tse bapalang karolo e fapaneng lits'ebetsong tsa baeloji 'me li na le thahasello e kholo ho fumanoeng le nts'etsopele ea lithethefatsi. Ka ho kenyelletsa N-Boc-O-Benzyl-D-serine ka tatellano ea li-peptide, litsebi tsa lik'hemik'hale li ka fetola thepa le mesebetsi ea li-peptide tse hlahang, e leng se etsang hore e be sesebelisoa sa bohlokoa moralong oa li-agent tse ncha tsa meriana. Ho feta moo, N-Boc-O-Benzyl-D-serine e sebelisoa ho lokiseng metsoako ea meriana le metsoako e sebetsang ea meriana (APIs). Ho sebetsa ha eona ka mokhoa o feto-fetohang le ho lumellana ha eona le liketso tse fapaneng tsa lik'hemik'hale ho etsa hore e be karolo e batloang haholo tlhahisong ea limolek'hule tse rarahaneng tsa tlhaho tse nang le bokhoni ba phekolo.
Tšobotsi
(1) Bohloeki bo phahameng: N-Boc-O-Benzyl-D-serine e ka fumana dihlahiswa tse hlwekileng haholo ka mekgwa ya tlhahiso ya ho hlwekisa. Bohloeki bo phahameng bo bolela ho fumaneha ha di-bioavailability tse betere le dikarabelo tse fokolang tse mpe.
(2) Polokeho: Polokeho e phahameng, dikarabelo tse fokolang tse mpe.
(3) Botsitso: N-Boc-O-Benzyl-D-serine e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng le maemo a polokelo.
Likopo
Ho kenyelletsoa ha N-Boc-O-Benzyl-D-serine ka har'a limolek'hule tsa meriana ho bontšitsoe ho fana ka thepa e lakatsehang ea pharmacokinetic le pharmacodynamic. Li-peptide tse nkiloeng ho N-Boc-O-Benzyl-D-serine li bontšitse botsitso bo ntlafetseng, ho fumaneha ha 'mele, le ho khetheha ha sepheo, e leng se etsang hore e be bakhethoa ba tšepisang bakeng sa kalafo ea mafu a fapaneng, ho kenyeletsoa kankere, mafu a tšoaetsanoang le mathata a methapo ea kutlo. Ho feta moo, bokhoni ba ho fetola karolo ea N-Boc-O-Benzyl-D-serine ka boikhethelo bo lumella ho lokisoa ha bakhethoa ba meriana, ho ntlafatsa katleho ea bona le liprofayili tsa polokeho.
