Moetsi oa phofo ea Lemairamin (WGX-50) Nomoro ea CAS: 29946-61-0 Bohloeki ba 98.0% bonyane bakeng sa metsoako ea tlatsetso
Video ea Sehlahisoa
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | Lemairamin |
| Lebitso le leng | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| Nomoro ea CAS | 29946-61-0 |
| Foromo ea limolek'hule | C19H21NO3 |
| Boima ba limolek'hule | 311.37 |
| Bohloeki | 98.0% |
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
| Kopo | Lisebelisoa tse Tala tsa Tlatsetso ea Lijo |
Selelekela sa sehlahisoa
Lemairamin kapa Wgx50 ke motsoako oa tlhaho o nkiloeng pepereng ea chili o bontšitseng liphello tse tšepisang ho thibela lefu la Alzheimer. Lithuto li fumane hore e ka thibela apoptosis ea neuronal e bakoang ke Aβ, ea fokotsa chefo ea calcium ea neuronal, le ho fokotsa ho bokellana ha li-oligomers tsa Aβ ka har'a cortex ea boko. Ho feta moo, wgx50 e bontšitsoe e ntlafatsa ts'ebetso ea kelello ho litoeba. Lipatlisiso li bontša hore wgx50 e na le bokhoni ba ho thibela kopano ea protheine-protein pakeng tsa limolek'hule tsa amyloid. Ka kakaretso, wgx50 e na le bokhoni ba ho thibela lefu la Alzheimer 'me e ka fana ka litsela tse ncha bakeng sa nts'etsopele ea meriana e shebaneng le li-oligomers tsa Aβ. Ho feta moo, WGX-50 e bontša ts'ebetso ea bohlokoa ea ho thibela ho ruruha, e leng se etsang hore e be mokhethoa ea tšepisang bakeng sa kalafo ea mafu a ho ruruha. WGX-50 e fumanoe e na le litlamorao tse kholo letlalong, joalo ka ho fokotsa makhopho le ho ntlafatsa ho tenyetseha ha letlalo. Ntle le metsoako ea tlhaho e nkiloeng semeleng sa Zanthoxylum bungeanum, hajoale ho na le metsoako e mengata ea maiketsetso e sebelisoang lits'ebetsong tse fapaneng 'me e loketse haholoanyane' marakeng.
Tšobotsi
(1) Bohloeki bo phahameng: Lemairamin e ka fumana dihlahiswa tse hlwekileng haholo ka ho ntsha le ho hlwekisa ka tlhaho. Bohloeki bo phahameng bo bolela ho fumaneha ha dihlahiswa hantle le dikarabelo tse fokolang tse mpe.
(2) Polokeho: Polokeho e phahameng, ditlamorao tse fokolang tse mpe, ha ho ditlamorao tse totobetseng tse mpe esita le ka tshebediso ya nako e telele.
(3) Botsitso: Lemairamin e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng a tikoloho le maemo a polokelo.
(4) Ho monya habonolo: Lemairamin e ka monngoa kapele ke 'mele oa motho 'me ea ajoa liseleng le lithong tse fapaneng.
Likopo
Lemairamin ke motsoako oa amide o nkiloeng makhapetleng a semela sa Zanthoxylum bungeanum. Hona joale e sebelisoa e le tlatsetso ea lijo, e boetse e sebetsa e le agonist ea alpha7 nicotinic acetylcholine receptor (α7nAChR), e fokotsang ho ruruha ha methapo ea kutlo lefung la Alzheimer, 'me e entsoe ka maiketsetso ka botlalo. Wgx50 e bontšitse liphetho tse khothatsang lithutong tsa pele ho kliniki, ho kenyeletsoa ho thibela apoptosis ea neuronal e bakoang ke Aβ, ho fokotsa chefo ea calcium ea methapo ea kutlo, ho fokotsa ho bokellana ha Aβ oligomers bokong ba boko, le ho ntlafatsa ts'ebetso ea kelello ho litoeba.
