Lemairamin (WGX-50) moetsi oa phofo CAS No.: 29946-61-0 98.0% bohloeki min.bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | Lemairamin |
| Lebitso le leng | 2-Propenamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-3-phenyl-, (2E)-; Lemairamin (WGX-50) |
| Nomoro ea CAS. | 29946-61-0 |
| Mokhoa oa limolek'hule | C19H21NO3 |
| Boima ba molek'hule | 311.37 |
| Bohloeki | 98.0% |
| Ponahalo | Phofo e tšoeu ho isa ho e tšoeu |
| Kopo | Tlatsetso ea Lijo tse tala |
Kenyelletso ea sehlahisoa
Lemairamin kapa Wgx50 ke motsoako oa tlhaho o ntšitsoeng pepereng o bonts'itseng litholoana tse ts'episang ho thibela lefu la Alzheimer's.Liphuputso li fumane hore e ka thibela Aβ-induced neuronal apoptosis, ea fokotsa chefo ea neuronal calcium, le ho fokotsa ho bokellana ha li-oligomers tsa Aβ ka har'a cerebral cortex.Ho feta moo, wgx50 e bontšitsoe ho ntlafatsa ts'ebetso ea kelello ho litoeba.Lipatlisiso li fana ka maikutlo a hore wgx50 e na le monyetla oa ho thibela kopano ea protheine-protein lipakeng tsa limolek'hule tsa amyloid.Ka kakaretso, wgx50 e na le monyetla oa ho thibela lefu la Alzheimer mme e ka fana ka mekhoa e mecha bakeng sa nts'etsopele ea litlhare tse shebaneng le Aβ oligomers.Ho feta moo, WGX-50 e bonts'a ts'ebetso ea bohlokoa e khahlanong le ho ruruha, e etsang hore e be mokhethoa ea ts'episang bakeng sa kalafo ea mafu a ho ruruha.WGX-50 e fumanoe e e-na le litlamorao tse kholo letlalong, joalo ka ho fokotsa makhopho le ho ntlafatsa ho tsitsa ha letlalo.Ho phaella ho metsoako ea tlhaho e ntšitsoeng semela sa Zanthoxylum bungeanum, hona joale ho na le metsoako e mengata ea maiketsetso e sebelisoang lits'ebetsong tse fapaneng 'me e loketse haholoanyane' marakeng.
Sebopeho
(1) Bohloeki bo phahameng: Lemairamin e ka fumana lihlahisoa tsa bohloeki bo phahameng ka ho ntša tlhaho le ho hloekisa mekhoa ea tlhahiso.Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: Tšireletseho e phahameng, liketso tse fokolang tse fokolang, ha ho na liketso tse mpe tse totobetseng esita le ka tšebeliso ea nako e telele.
(3) Botsitso: Lemairamin e na le botsitso bo botle 'me e ka boloka ts'ebetso ea eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
(4) Ho bonolo ho monya: Lemairamin e ka monngoa kapele ke ’mele oa motho ’me ea abeloa lisele le litho tse sa tšoaneng.
Lisebelisoa
Lemairamin ke motsoako oa amide o ntšitsoeng lekhapetleng la semela sa Zanthoxylum bungeanum.Hona joale e sebelisoa e le tlatsetso ea lijo, e boetse e sebetsa e le agonist ea alpha7 nicotinic acetylcholine receptor (α7nAChR), e fokotsang neuroinflammation ho lefu la Alzheimer's, 'me e entsoe ka ho feletseng.Wgx50 e bontšitse liphello tse khothatsang lithutong tsa preclinical, ho akarelletsa le ho thibela Aβ-induced neuronal. apoptosis, ho fokotsa chefo ea neuronal calcium, ho fokotsa ho bokellana ha li-oligomers tsa Aβ ka har'a cerebral cortex, le ho ntlafatsa ts'ebetso ea kelello ho litoeba.
