5-Amino-1-methylquinolinium iodide（NNMTi） Nomoro ea CAS:42464-96-0 Bohloeki ba 98.0% bonyane | moetsi oa metsoako ea tlatsetso
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | 5-Amino-1-methylquinolinium iodide (NNMTi) |
| Lebitso le leng | NNTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODide 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; iodide Iodide ea 5-Amino-1-methyl-1-quinolinium iodide ea 5-Amino-1-mq |
| Nomoro ea CAS | 42464-96-0 |
| Foromo ea limolek'hule | C10H11IN2 |
| Boima ba limolek'hule | 286.11 |
| Bohloeki | 98.0% |
| Ponahalo | Sootho ho isa ho bofubelu bo sootho bo tiileng |
| Ho paka | 1kg/mokotla, 25kg/barele |
| Kopo | Lisebelisoa tse Tala tsa Tlatsetso ea Lijo |
Selelekela sa sehlahisoa
Enzyme ea cytosolic nicotinamide N-methyltransferase (NNMT) e sa tsoa sibolloa ho laola maemo a li-precursor tsa nicotinamide tse hlokahalang bakeng sa biosynthesis ea NAD+ 'me ka hona e bapala karolo ea bohlokoa ho laoleng tsela ea pholoho ea NAD+ le metabolism ea sele. NNMT e hlahisoa mesifa ea masapo, 'me tlhahiso ea eona e eketseha butle-butle ka botsofali ba lisele tsa mesifa. Habohlokoa, NNMT ke karolo e kholo ea saena ea polelo ea liphatsa tsa lefutso ea sarcopenic, 'me tlhahiso ea eona e feteletseng e ka lebisa ho fokotseha ho hoholo maemong a NAD+ le ho fokotseha ha mesifa, matla le ts'ebetso e tsamaeang le botsofali. Kalafo ea litoeba tse tsofetseng ka molek'hule e nyane ea NNMT inhibitor (NNMTTi) e ntlafalitse kholo, ho kopana le bokhoni ba ho nchafatsa li-muSC, ka hona ho ntlafatsa ts'ebetso ea ts'ebetso ea mesifa ea masapo. Liphetho tse tšoanang li fumanoe ka vitro ho sebelisoa lisele tsa C2C12, tse tšoanang haholo le li-muSC, moo kalafo ea NNMTTi e khothalelitseng phapang ea myoblast le ho tšehetsa liphetoho tsa metabolism li-metabolite tsa sele tse amanang le tsela ea pholoho ea NAD +.
NNMT ke enzyme e hlahisoang haholo nakong ea botsofali ba mesifa ea masapo 'me e amahanngoa le tšenyo tseleng ea NAD+, ts'ebetso e sa laoleheng ea sirtuin1, le keketseho ea botsofali ba lisele tsa mesifa. NNMT ke enzyme ea metabolism e susumetsang methylation ea nicotinamide (NAM) e sebelisa methyl donor S-adenosylmethionine (SAM) ea bokahohleng, e hokahanyang boemo ba metabolism ea sele le tekanyo ea methylation le maemo a NAD+ a ka hare ho sele. NNMT e hlahisoa haholo liseleng tsa sebete le mafura, hammoho le maemong a pathological a khetholloang ke litlhoko tse eketsehileng tsa metabolism, joalo ka mafu a itseng a sebete a mafura le lefu la tsoekere. NNMT e ameha lits'ebetsong tse fapaneng tsa phapang, ho kenyeletsoa phetoho ea lisele tsa motheo tsa motho tse sa tsoa emoloa ho ea ho tse holileng, myogenesis, le liphetoho tsa epithelial le neuromesenchymal mofetšeng o fapaneng. Ponahalo ea NNMT e laoloa ka mokhoa o ikhethileng oa lisele le moelelo ho fapana le ka mokhoa o tloaelehileng oa taolo.
Tšobotsi
(1) Bohloeki bo phahameng: NNMTi e ka fumana dihlahiswa tse hlwekileng haholo ka mekgwa ya tlhahiso e hlwekileng. Bohloeki bo phahameng bo bolela ho fumaneha ha dihlahiswa hantle.
(2) Ho Lebisa: NNMT e shebana ka ho khetheha le enzyme ea NNMT 'me e ka thibela ts'ebetso ea eona ka katleho, ka hona e ama tsela ea metabolism ea nicotinamide.
(3) Botsitso: NNMTi e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng a tikoloho le maemo a polokelo.
(4) Litebello tsa nts'etsopele: Ka lebaka la litšobotsi tse fapaneng tsa NNMTi, nts'etsopele ea eona e amohetse tlhokomelo e pharalletseng 'me e na le litebello tse pharaletseng tsa lipatlisiso le ts'ebeliso.
Likopo
NNMTi (CAS 42464-96-0) ke sethibela-mafu sa nicotinamide N-methyltransferase (NNMT), sethibela-mafu se matla (IC50=1.2 μM) sa nicotinamide N-methyltransferase (NNMT) se khothalletsang phapang ea myoblast. NNMTi e tlama ka mokhoa o ikhethileng masala a sebaka sa ho tlama substrate sa NNMT. NNMTi e khothalletsa phapang ea myoblast ka vitro mme e ntlafatsa ho kopanngoa ha lisele tsa stem tsa mesifa le tsosoloso ho litoeba tse tsofetseng. NNMT ke enzyme ea motheo ea cytosolic biotransformation e susumetsang N-methylation ea li-xenobiotics tsa tlhaho le tsa kantle. Ha e bapisoa le ho nkeloa sebaka ha lijo tse se nang mafura feela, kalafo ea NNMTi e kopantsoeng le ho nkeloa sebaka ha lijo tse se nang mafura e potlakisa ntlafatso ea tahlehelo ea mafura a 'mele, e eketsa boima ba' mele oohle ho ea ka karolelano ea boima ba 'mele, e fokotsa boima ba lisele tse tšoeu tsa mafura a sebete, e fokotsa ho bolokoa ha mafura a sebete, le steatosis e ntlafetseng ea sebete. Ho phaella moo, NNMTi e ka eketsa matla le ho khothaletsa bokhoni ba ho tsosolosa ba mesifa e tsofetseng, e leng se ka bang molemo bakeng sa kalafo ea sarcopenia.
