CMS121 moetsi oa phofo CAS No.: 1353224-53-9 98.0% bohloeki min. bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | CMS121 |
| Lebitso le leng | CMS-121; 1,2-Benzenediol,4--[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC,AcetylCoenzymeACarboxylase, lefu, neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoACarboxylase,CMS121,dementia,ACC1,CMS-121 |
| Nomoro ea CAS. | 1353224-53-9 |
| Mokhoa oa limolek'hule | C20H19NO3 |
| Boima ba molek'hule | 321.37 |
| Bohloeki | 98.0% |
| Ponahalo | Phofo e mosehla e khanyang |
| Kopo | Tlatsetso ea Lijo tse tala |
Kenyelletso ea sehlahisoa
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ke motsoako o boetseng o bitsoa CMS121. Ho rarahana ha motsoako ona ho fana ka maikutlo a hore e kanna ea ba le thepa e ikhethang le ts'ebeliso e ka bang teng. Ho utloisisa bohlokoa ba eona, e thusa ho khetholla lihlopha tse sebetsang tse teng le ho sekaseka phello e ka bang teng. Ho ba teng ha reng ea quinoline ho fana ka maikutlo a hore motsoako ona o ka ba le ts'ebetso ea baeloji. Limolek'hule tse nkiloeng ho quinoline li tsejoa ka mefuta ea tsona ea tlhaho e fapaneng, ho kenyeletsoa mesebetsi ea antibacterial le anti-inflammatory. Ho khomarela sehlopha sa cyclopentyloxy ho ka kenya letsoho ho solubility ea motsoako kapa ho ntlafatsa ts'ebetso ea eona ea likokoana-hloko ka liphello tsa steric. Lithutong tsa lisele tsa HT22, CMS-121 e bonts'itse litlamorao tse kholo tsa neuroprotective, ho sireletsa lisele tsena ka katleho ho tsoa ho ischemia le tšenyo ea oxidative. Ho feta moo, CMS-121 e na le thepa ea bohlokoa e khahlanong le ho ruruha, e bontšang bokhoni ba eona ba ho fetola likarabo tsa ho ruruha. Ka ho etsa joalo, CMS-121 e na le monyetla oa ho fokotsa ho ruruha ha lisele le litho tse fapaneng. CMS-121 e na le ts'ebetso e matla ea pharmacological e le inhibitor ea acetyl-CoA carboxylase 1 (ACC1). Tšusumetso ea eona e matla ea ho thibela ACC1 e e etsa motsoako o ts'episang.
Sebopeho
(1) Bohloeki bo phahameng: CMS-121 e ka fumana lihlahisoa tse phahameng tsa bohloeki ka mekhoa e hloekisitsoeng ea tlhahiso. Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: Tšireletseho e phahameng, liketso tse seng kae tse mpe.
(3) Botsitso: CMS-121 e na le botsitso bo botle 'me e ka boloka ts'ebetso ea eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
Lisebelisoa
CMS-121 ke inhibitor e tsoang ho quinolone le e sebetsang ka molomo ea acetyl-CoA carboxylase 1 (ACC1) e nang le thepa e tšepisang ea meriana. Ho entsoe lipatlisiso tse pharaletseng ho batlisisa melemo e ka bang teng ea CMS-121 libakeng tse sa tšoaneng, ho akarelletsa le neuroprotection, anti-inflammatory effects, antioxidant activity, le phello ea eona ho matšoao a amanang le botsofali bo botle.
