Moetsi oa phofo oa CMS121 Nomoro ea CAS: 1353224-53-9 Bohloeki ba 98.0% bonyane bakeng sa metsoako ea tlatsetso
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | CMS121 |
| Lebitso le leng | CMS-121; 1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-; 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol(CMS121); ACC, AcetylCoenzymeACarboxylase, lefu, le sireletsang methapo ea kutlo, le thibela, le thibelang ho ruruha, mitochondrial, Alzheimer's, le thibelang oksideiti, acetylation, le thibelang, H3K9, Acetyl-CoACarboxylase, CMS121, letšollo la kelello, ACC1, CMS-121 |
| Nomoro ea CAS | 1353224-53-9 |
| Foromo ea limolek'hule | C20H19NO3 |
| Boima ba limolek'hule | 321.37 |
| Bohloeki | 98.0% |
| Ponahalo | Phofo e mosehla o bobebe |
| Kopo | Lisebelisoa tse Tala tsa Tlatsetso ea Lijo |
Selelekela sa sehlahisoa
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol ke motsoako o boetseng o bitsoa CMS121. Ho rarahana ha sebopeho sa motsoako ho bontša hore o ka ba le thepa e ikhethang le ts'ebeliso e ka bang teng. Ho utloisisa bohlokoa ba oona, ho thusa ho khetholla lihlopha tse sebetsang tse teng le ho sekaseka tšusumetso ea tsona e ka bang teng. Boteng ba lesale la quinoline bo bontša hore motsoako o ka ba mafolofolo ka baeloji. Limolek'hule tse tsoang ho Quinoline li tsejoa ka thepa ea tsona e fapaneng ea baeloji, ho kenyeletsoa mesebetsi ea antibacterial le anti-inflammatory. Ho khomarela sehlopha sa cyclopentyloxy ho ka kenya letsoho ho qhibiliheng ha motsoako kapa ho ntlafatsa ts'ebetso ea oona ea baeloji ka litlamorao tsa steric. Lithutong tse mabapi le lisele tsa HT22, CMS-121 e bontšitse litlamorao tse kholo tsa ts'ireletso ea methapo, e sireletsa lisele tsena ka katleho ho ischemia le tšenyo ea oxidative. Ho feta moo, CMS-121 e na le thepa e kholo ea ho thibela ho ruruha, e bontšang bokhoni ba eona ba ho fetola likarabo tsa ho ruruha. Ka ho etsa joalo, CMS-121 e na le bokhoni ba ho fokotsa ho ruruha liseleng le lithong tse fapaneng. CMS-121 e na le ts'ebetso e matla ea meriana e le thibelo ea acetyl-CoA carboxylase 1 (ACC1). Tšusumetso ea eona e matla ea thibelo ho ACC1 e etsa hore e be motsoako o tšepisang.
Tšobotsi
(1) Bohloeki bo phahameng: CMS-121 e ka fumana dihlahiswa tse hlwekileng haholo ka mekgwa ya tlhahiso e hlwekileng. Bohloeki bo phahameng bo bolela ho fumaneha ha dihlahiswa hantle le dikarabelo tse fokolang tse mpe.
(2) Polokeho: Polokeho e phahameng, dikarabelo tse fokolang tse mpe.
(3) Botsitso: CMS-121 e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng le maemo a polokelo.
Likopo
CMS-121 ke sethibela-mafu sa acetyl-CoA carboxylase 1 (ACC1) se tswang ho quinolone le se sebetsang ka molomo se nang le thepa e tshepisang ya dikhemikhale. Diphuputso tse pharaletseng di entswe ho batlisisa melemo e ka bang teng ya CMS-121 dibakeng tse fapaneng, ho kenyeletswa tshireletso ya methapo ya kutlo, ditlamorao tsa ho thibela ho ruruha, mosebetsi wa antioxidant, le tshusumetso ya yona matshwaong a amanang le botsofadi bo phetseng hantle.
