Galantamine Hydrobromide phofo moetsi CAS No.: 1953-04-4 98% bohloeki min. bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | Galantamine Hydrobromide |
| Lebitso le leng | galanthamine hydrobromide; Galantamine HBr; Galanthamine HBr;(4aS,6R,8aS)-4a,5,9,10,11,12-hexahydro-3-methoxy-11-methyl-6H-Benzofuro[3a,3,2-ef][2]benzazepin- 6-ol, Hydrobromide |
| Nomoro ea CAS. | 1953-04-4 |
| Mokhoa oa limolek'hule | C17H21NO3.HBr |
| Boima ba molek'hule | 368.27 |
| Bohloeki | 98.0% |
| Ponahalo | phofo e tshweu ho isa ho bosweu |
| Ho paka | 1kg / mokotla 10kgs, 25kgs / moqomo |
| Kopo | lithethefatsi tsa nootropic |
Kenyelletso ea sehlahisoa
Galantamine hydrobromide ke benzazepine e nkiloeng ho bulbs le lipalesa tsa narcissus, osmanthus kapa canna. Hape ke molomo oa cholinesterase inhibitor. Joaloka ligand bakeng sa li-receptor tsa nicotinic acetylcholine, e 'nile ea sebelisoa haholo ho ntlafatsa ts'ebetso ea methapo ea kutlo. Mosebetsi oa eona ke ho thibela acetylcholinesterase ka tlholisano le ka mokhoa o feto-fetohang, ka hona ho eketsa bongata ba acetylcholine. Ha e kenngoa maling, galantamine hydrobromide e kenella habonolo likarolong tse sa tšoaneng tsa 'mele, ho akarelletsa le boko. E tlama ho li-receptor tsa nicotinic acetylcholine, e bakang liphetoho tsa conformational le ho eketsa tokollo ea acetylcholine. E boetse e sebetsa ka ho qothisana lehlokoa le ho khutlisa litlamorao tsa li-inhibitors tsa cholinesterase. Ka ho thibela cholinesterase, e thibela ho senyeha ha acetylcholine, kahoo e eketsa maemo le nako ea neurotransmitter ena e matla. Galantamine e ka boela ea ntlafatsa ho ithuta le mohopolo, ho thibela ho ruruha ha boko, le ho boloka maemo a phahameng a li-neurotransmitters ka ho boloka botšepehi ba methapo ea kutlo le li-synapses.
Sebopeho
(1) bohloeki bo phahameng: Galantamine hydrobromide e ka ba sehlahisoa sa bohloeki bo phahameng ka ho hloekisa mekhoa ea tlhahiso. Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: Galantamine hydrobromide e ipakile e sireletsehile bakeng sa 'mele oa motho.
(3) Botsitso: Galantamine hydrobromide e na le botsitso bo botle 'me e ka boloka mosebetsi oa eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
Lisebelisoa
E le tlatsetso ea lijo, galantamine hydrobromide e ka ntlafatsa mohopolo, kelello, le bokhoni ba ho etsa mesebetsi ea letsatsi le letsatsi. E sebetsa ka ho tsosolosa ho leka-lekana ha lintho tse itseng tsa tlhaho (li-neurotransmitters) bokong, e leng ho eketsang lebelo la ho theha mohopolo le ho ntlafatsa ho boloka lintlha le lintlha. Ho feta moo, galantamine hydrobromide e ama ka ho toba kapa ka tsela e sa tobang neuroplasticity. E susumetsa polasetiki ea synaptic ka ho kenya tšebetsong microglia le astrocyte. Galantamine e fana ka tšireletso ea antioxidant khahlanong le khatello ea oxidative e bakoang ke li-radicals tsa mahala.
