RU58841 moetsi oa phofo CAS No.: 154992-24-2 99.0% bohloeki min. bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | 4-[3-(4-Hydroxybutyl) -4,4-dimethyl-2,5-dioxo-1-imidazolidinyl] -2-(trifluoromethyl)benzonitrile |
| Lebitso le leng | RU58841 |
| Nomoro ea CAS. | 154992-24-2 |
| Mokhoa oa limolek'hule | C17H18F3N3O3 |
| Boima ba molek'hule | 369.34 |
| Bohloeki | 99.0% |
| Ponahalo | phofo e tšoeu |
| Ho paka | 1kg/ mokotla |
| Kopo | Holisa moriri |
Kenyelletso ea sehlahisoa
RU58841 (eo hape e tsejoang e le RU-58841) ke motsoako, RU58841 e hlōlisana le dihydrotestosterone ho boloka maemo a DHT ka har'a mefuta e tloaelehileng, kahoo e laola potoloho ea ho hōla ha moriri. E susumetsa phetoho ea li-follicles tse ncha tsa moriri ho li-follicle tsa moriri oa anagen ka ho kena karolong ea anagen. Ho lumella li-follicles tse senyehileng nako hore li fetohe ho khutlela karolong e tloaelehileng ea kholo ho thusa lisele hore li hlaphoheloe. E boetse e eketsa phallo ea mali ho follicles e senyehileng mme e ba thusa ho tsosolosa. Ka lehlakoreng le leng, RU58841 (RU-58841) e sebetsa ka ho tlama li-receptor tsa androgen ho li-follicle tsa moriri. Kahoo li-androgens ha li na monyetla oa ho tlama le ho qala karabelo ea ketane ea alopecia ea androgenetic le ho qala ts'ebetso e bitsoang miniaturization. Ho bontšitsoe sebakeng sa heno ho sitisa molaetsa ona oa ho lahleheloa ke moriri e le hore ho hōla ha moriri ho tloaelehileng ho ka tsoela pele.
Sebopeho
(1) E ka thibela ho lahleheloa ke moriri: RU58841 ke inhibitor e khethehileng ea hormone, e ka thibelang motsoako oa androgen le lisele tsa moriri oa moriri oa hlooho, kahoo o fokotsa kotsi ea ho lahleheloa ke moriri.
(2) Ho monya hantle: RU58841 e na le boima bo bonyenyane ba molek'hule, mohaho o bonolo, 'me o bonolo ho o amohela. E ka kena 'meleng ka potlako' me ea sebetsa ka nako e khutšoanyane.
(3) Khetho e phahameng ho androgen: RU58841 e ka thibela ka mokhoa o ikhethileng ketso ea androgen ntle le ho ama lihomone tse ling.
(4) Nako e telele ea ketso: RU58841 e na le halofo ea nako e telele 'meleng, e ka thibela ka ho tsoelang pele phello ea androgen,' me nako e sebetsang e ka ba lihora tse 48.
(5) Bohloeki bo phahameng: Ka tlhahiso ea tlhaho le mokhoa o motle oa ho etsa lihlahisoa, nts'etsopele ea RU58841 e ka fumana lihlahisoa tse phahameng tsa bohloeki.
Lisebelisoa
Lipatlisisong le litekong tsa meriana, RU58841 e bontšitsoe ho eketsa sekhahla sa ho ikatisa ha lisele liseleng tsa stromal, ho eketsa ho ata ha lisele ka lisele tsa metso e ka ntle le ho eketsa bophara ba moriri le moriri oa moriri, kahoo RU58841 ke lithethefatsi tsa lipatlisiso bakeng sa phekolo ea alopecia ea androgenetic. Molao-motheo o ka sehloohong oa ho sebetsa ke ho thibela motsoako oa DHT le AR oa li-follicles tsa moriri, tse atisang ho sebelisoa ho phekola ho lahleheloa ke moriri le mathata a ho lahleheloa ke moriri.
