YDL223C (HBT1) moetsi oa phofo CAS No.: 489408-02-8 99% bohloeki min.bakeng sa lisebelisoa tsa tlatsetso
Lihlahisoa tsa lihlahisoa
| Lebitso la sehlahisoa | HBT1 |
| Lebitso le leng | YDL223C |
| Nomoro ea CAS. | 489408-02-8 |
| Mokhoa oa limolek'hule | Setšoantšo sa C16H17F3N4O2S |
| Boima ba molek'hule | 386.40 |
| Bohloeki | 99.0% |
| Ponahalo | Bosehla bo kganyang bo tiileng |
| Ho paka | 1kg ka mokotla 25kg ka moropa |
| Kopo | lithethefatsi tsa nootropic |
Kenyelletso ea sehlahisoa
HBT1 e tlamella sebakeng se tlamang ligand sa α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA-R) ka mokhoa o itšetlehileng ka glutamate.Sena se bolela hore HBT1 ke molek'hule e ka tlamang feela libakeng tse itseng tsa protheine ea AMPA-R ha glutamate e le teng, le hore tlamahano ena e thusa ho laola tšebetso ea protheine.Li-receptor tsa AMPA li hlahisoa ho pholletsa le tsamaiso ea methapo e bohareng 'me li phetha karolo ea bohlokoa puisanong ea neuronal, ts'ebetso ea kutlo, le ho ithuta, mohopolo le polasetiki ea synaptic.Li-receptor tsa AMPA ke tsona tse kenyang letsoho ho pharalletseng ha methapo ea kutlo, ho kenella ka potlako, ka potlako ho felloa ke maikutlo ka potlako ea li-synapse tse ngata, 'me li kenya letsoho likarabelong tsa pele tsa libaka tsa synaptic ho glutamate.Li-receptor tsa AMPA li atisa ho kopanngoa le li-receptor tsa NMDA ho li-synapse, 'me hammoho li khothalletsa mekhoa ea polasetiki ea synaptic e amehang ho ithuteng, ho hopola, ho thaba le ho sireletsa methapo ea pelo.
Sebopeho
Brain-derived neurotrophic factor (BDNF) ke neurotrophic factor e bapalang karolo ea bohlokoa tlhokomelong le katolosong ea methapo ea kutlo, 'me e na le litlamorao tse matla le tse ngata ho ata, ho arola, ho phela le ho shoa ha lisele tsa neuronal le tseo e seng tsa methapo, modulator ea neurotransmitter mme e kenya letsoho ho polasetiki ea neuronal bakeng sa ho ithuta le mohopolo.Ka hona ke ea bohlokoa bakeng sa bophelo bo botle le boiketlo ba tsamaiso ea methapo.Keketseho ea BDNF e ka ipaka e thusa ho phekola le ho thibela mafu a mangata.
Lisebelisoa
HBT1 ke novel AMPA receptor enhancer e nang le agonism e tlase ha e bapisoa le LY451395 le OXP1, e hlohlelletsa tlhahiso ea boko-derived neurotrophic factor (BDNF), mme e bonts'a phello e nyane ho pherekano ea mantlha ea methapo.HBT1 e tlamella sebakeng se tlamang ligand sa AMPA-R ka mokhoa o itšetlehileng ka glutamate.Ka kopanelo, ba khothaletsa lits'ebetso tsa polasetiki tsa synaptic tse amehang ho ithuteng, ho hopola, ho hlasimoloha le ts'ireletso ea methapo.E ka ntlafatsa bokhoni ba kelello le mohopolo oa boko, le ho ntlafatsa bokhoni ba batho ba ho ithuta.
