Moetsi oa phofo oa RU58841 Nomoro ea CAS: 154992-24-2 Bohloeki ba 99.0% bonyane bakeng sa metsoako ea tlatsetso
Liparamente tsa Sehlahisoa
| Lebitso la sehlahisoa | 4-[3-(4-Hydroxybutyl)-4,4-dimethyl-2,5-dioxo-1-imidazolidinyl]-2-(trifluoromethyl)benzonitrile |
| Lebitso le leng | RU58841 |
| Nomoro ea CAS | 154992-24-2 |
| Foromo ea limolek'hule | C17H18F3N3O3 |
| Boima ba limolek'hule | 369.34 |
| Bohloeki | 99.0% |
| Ponahalo | phofo e tšoeu |
| Ho paka | 1kg/mokotla |
| Kopo | Holisa moriri |
Selelekela sa sehlahisoa
RU58841 (e tsejoang hape e le RU-58841) ke motsoako, RU58841 e qothisana lehlokoa le dihydrotestosterone ho boloka maemo a DHT a le maemong a tloaelehileng, ka hona e laola potoloho ea kholo ea moriri. E susumetsa phetoho ea li-follicle tse ncha tsa moriri ho li-follicle tsa moriri tsa anagen ka ho kena mohatong oa anagen. Ho lumella li-follicle tse senyehileng nako ea ho khutlela mohatong o tloaelehileng oa kholo ho thusa lisele ho hlaphoheloa. E boetse e eketsa phallo ea mali ho li-follicle tse senyehileng 'me e li thusa ho itsosolosa. Ka lehlakoreng le leng, RU58841 (RU-58841) e sebetsa ka ho tlama li-receptor tsa androgen ho li-follicle tsa moriri. Kahoo li-androgen ha li na monyetla oa ho tlama le ho qala karabelo ea ketane ea androgenetic alopecia le ho qala ts'ebetso e bitsoang miniaturization. Ho bontšitsoe hore sebakeng seo ho sitisa molaetsa ona oa tahlehelo ea moriri e le hore kholo e tloaelehileng ea moriri e ka tsoela pele.
Tšobotsi
(1) E ka thibela tahlehelo ea moriri: RU58841 ke thibelo e khethehileng ea lihormone, e ka thibelang motsoako oa lisele tsa follicle ea moriri oa androgen le oa letlalo la hlooho, ka hona e fokotsa kotsi ea tahlehelo ea moriri.
(2) Ho monya hantle: RU58841 e na le boima bo bonyenyane ba limolek'hule, sebopeho se bonolo, 'me e bonolo ho monya. E ka kena ka potlako 'meleng' me ea sebetsa ka nako e khutšoanyane.
(3) Khetho e phahameng ho androgen: RU58841 e ka thibela ketso ea androgen ka khetho ntle le ho ama lihormone tse ling.
(4) Nako e telele ea ts'ebetso: RU58841 e na le halofo ea bophelo bo bolelele 'meleng, e ka thibela ts'ebetso ea androgen khafetsa, 'me nako e sebetsang e ka ba lihora tse 48.
(5) Bohloeki bo phahameng: Ka ho ntša lintho tsa tlhaho le ts'ebetso ea tlhahiso e ntle, nts'etsopele ea RU58841 e ka fumana lihlahisoa tse hloekileng haholo.
Likopo
Lipatlisisong le litekong tsa bongaka, RU58841 e bontšitsoe e eketsa sekhahla sa ho ikatisa ha lisele liseleng tsa stromal, e eketsa ho ata ha lisele liseleng tsa root sheet tse ka ntle le ho eketsa bophara ba moriri le botenya ba moriri, kahoo RU58841 ke moriana o etsoang lipatlisiso bakeng sa kalafo ea androgenetic alopecia. Molao-motheo o ka sehloohong o sebetsang ke ho thibela motsoako oa DHT le AR oa li-follicle tsa moriri, tse atisang ho sebelisoa ho phekola mathata a ho lahleheloa ke moriri le ho lahleheloa ke moriri.
