Moetsi oa phofo ea Agomelatine CAS No.: 138112-76-2 99% bohloeki min. bakeng sa lisebelisoa tsa tlatsetso
Video ea Sehlahisoa
Lihlahisoa tsa lihlahisoa
Lebitso la sehlahisoa | Agomelatine |
Lebitso le leng | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
Nomoro ea CAS. | 138112-76-2 |
Mokhoa oa limolek'hule | C15H17NO2 |
Boima ba molek'hule | 243.3082 |
Bohloeki | 99.0% |
Ponahalo | Phofo e tšoeu |
Ho paka | 1kg/ mokotla 25kg / moropa |
Kopo | Health sehlahisoa lihlahisoa tse tala |
Kenyelletso ea sehlahisoa
Agomelatine e qalile ho thakholoa Europe ka 2009 'me joale e amohetsoe ho sebelisoa linaheng tse fetang 70. Ho fapana le li-antidepressants tsa setso, agomelatine e sebetsa ka ho lebisa melatonin le li-receptor tsa serotonin bokong. Ka ho sebetsa joalo ka agonist ho li-receptor tsa melatonin, agomelatine e thusa ho tloaetsa mekhoa ea boroko e sitisang hangata e amanang le khatello ea maikutlo. Mokhoa ona ha o thuse feela ho ntlafatsa boleng ba boroko empa hape o thusa ho khutlisetsa morethetho oa tlhaho oa circadian. Ho feta moo, agomelatine e sebetsa e le mohanyetsi ho li-receptor tse itseng tsa serotonin (5-HT2C receptors). Ketso ena e ikhethang e habeli ka tsela e sa tobang e ntlafatsa boteng ba serotonin bokong, neurotransmitter e ikarabellang bakeng sa ho laola maikutlo. Ka ho laola maemo a serotonin, agomelatine e ka sebetsa e le sethethefatsi se atlehang sa ho tepella maikutlo, se imollang matšoao a kang ho hlonama, ho lahleheloa ke thahasello, maikutlo a molato kapa ho hloka thuso. Ho feta moo, agomelatine e ka fana ka melemo e meng. Patlisiso e fana ka maikutlo a hore e ka thusa ho ntlafatsa ts'ebetso ea kelello Patlisiso e bonts'a bokhoni ba eona ba ho ntlafatsa mohopolo, tlhokomelo, le ts'ebetso ea tsamaiso, e e etsa sebaka se thabisang sa lipatlisiso tsa kamoso.
Sebopeho
(1) Bohloeki bo phahameng: Agomelatine e ka fumana lihlahisoa tse hloekileng ka ho hloekisa mekhoa ea tlhahiso. Bohloeki bo phahameng bo bolela bioavailability e betere le ho fokotseha ho hoholo ha maikutlo.
(2) Tšireletseho: Tšireletseho e phahameng, liketso tse seng kae tse mpe.
(3) Botsitso: Agomelatine e na le botsitso bo botle 'me e ka boloka ts'ebetso ea eona le phello tlas'a maemo a fapaneng le maemo a polokelo.
Lisebelisoa
Agomelatine ke antidepressant le mohanyetsi oa melatonin. E fokotsa matšoao a tepeletseng maikutlo ka ho laola melatonin MT1 receptors (e fokotsa matšoao a cortical alarm) le MT2 receptors (circadian sleep rhythm) le maemo a serotonin. E nkuoa bosiu, e etsisa morethetho oa tlhaho oa ho lokolloa ha melatonin 'me e ka ntlafatsa boleng ba boroko haholo. Mokhoa oa eona oa ts'ebetso o phunyeletsa ka mokhoa oa setso oa ho fetisa monoamine. E kenya tšebetsong li-receptor tsa melatonin MT1 le MT2 mme e hanyetsa li-receptor tsa 5-HT2C. E ntlafatsa boleng ba boroko, e khutlisetsa morethetho oa tlhaho, 'me e na le phello e thibelang ho imeloa kelellong; har'a bona, ka ho hanyetsa li-receptor tsa 5-HT2C ka lera la postsynaptic, e ka eketsa ho lokolloa ha DA le NE ka har'a prefrontal cortex, ho fana ka phello e thibelang ho imeloa kelellong. Ha MT agonism le 5-HT2C receptor antagonism li kopane, ho ka hlahisoa phello e ikhethang ea synergistic, e khothalletsang ho lokolloa ha DA le NE ho feta sebakeng sa boko ba PFC, ho matlafatsa ka ho eketsehileng phello ea ho tepella maikutlo. Ho phaella moo, agomelatine e ka khothalletsa ho lokolloa ha boko bo entsoeng ke neurotrophic factor PFC le ho thibela ho lokolloa ha glutamate ka lebaka la khatello ea kelello sebakeng sa boko ba amygdala.