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sehlahisoa

Moetsi oa phofo ea Compound 7P Nomoro ea CAS: 1890208-58-8 Bohloeki ba 99% bonyane bakeng sa metsoako ea tlatsetso

Tlhaloso e Khutšoanyane:

Ho bontšitsoe hore Compound 7p e baka kholo ea li-axon tse ntle tsa GAP-43 mohlaleng oa phoofolo oa kotsi ea methapo ea optic, e leng se bontšang hore ts'ebetso ea kholo ea neurite ea compound 7p in vitro e fetolela ho hlohlelletsa tsosoloso ea axon in vivo.


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7P e kopaneng

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Compound7P;2-[(2-methoxyphenyl)[(4-methylphenyl)sulfonyl]amino]-N-(4-methoxy-3-pyridinyl)acetamide;

2-(N-(2-methoxyphenyl)-4-methylphenylsulfonamido)-N-(4-methoxypyridin-3-yl)acetamide

Nomoro ea CAS

1890208-58-8

Foromo ea limolek'hule

C22H23N3O5S

Boima ba limolek'hule

441.51

Bohloeki

99.0%

Ponahalo

Phofo e tšoeu

Kopo

Nootropic

Selelekela sa sehlahisoa

Compound 7P e bolela motsoako o itseng oa tlhaho o nang le liathomo tse supileng tsa khabone. K'hemistring ea tlhaho, khabone ke ntho ea bohlokoa hobane e ka theha maqhama a tsitsitseng le liathomo tse ling, ho kenyeletsoa le liathomo tsa khabone, ho etsa limolek'hule tse rarahaneng. Limolek'hule tsena li ka ba le litšobotsi le mesebetsi e fapaneng, e leng se etsang hore metsoako e thehiloeng khaboneng e be motheo oa bophelo. Mehlaleng ea liphoofolo ea kotsi ea methapo ea optic, compound 7p e bontšitsoe e susumetsa kholo ea li-axon tse ntle tsa GAP-43, e leng se bontšang hore ts'ebetso ea kholo ea neurite ea compound 7p in vitro e fetolela ho tsosolosoeng ha axonal in vivo. Phofo ea Compound 7P ke phofo e tšoeu ho isa ho e tšoeu e hlahisoang e le motsoako oa tandem bakeng sa ho khetholla li-inhibitor tsa thromboxane receptor antagonist tse sebetsang habeli. Ha e le hantle, compound 7p e bontšitse khetho bakeng sa prostaglandin I2 synthase (PTGIS, CYP8A1) ha e bapisoa le thromboxane synthase (CYP5A1). Phofo ea nootropic compound 7P e khothalletsa kholo ea li-axon tse ntle tsa Gap-43, ka hona e susumetsa tsosoloso ea axonal 'meleng. Complex 7p ea boleng bo holimo e etselitsoe ho ntlafatsa tšebelisano-'moho, ho ntlafatsa maikutlo le ho thusa ho loantša mokhathala. E boetse e thibela oxidation ea boko 'me e thusa ho loantša tšenyo ea boko e bakoang ke ho noa joala.

Tšobotsi

结构图

(1) Bohloeki bo phahameng: Compound 7P e ka fumana dihlahiswa tse hlwekileng haholo ka mekgwa ya tlhahiso e hlwekileng. Bohloeki bo phahameng bo bolela ho fumaneha ha dihlahiswa hantle le dikarabelo tse fokolang tse mpe.

(2) Polokeho: Compound 7P e pakiloe e bolokehile bakeng sa 'mele oa motho.

(3) Botsitso: Compound 7P e na le botsitso bo botle mme e ka boloka ts'ebetso le phello ea eona tlas'a maemo a fapaneng a tikoloho le maemo a polokelo.

Likopo

Compound 7p e ntlafatsa kgolo ya neurite ya di-neuron tsa mantlha tse hodisitsweng tse tswang ho hippocampus, cerebral cortex, le retina mme e baka tsosoloso ya methapo ya optic mefuteng ya diphoofolo ya kotsi ya methapo ya optic. E boetse e ntlafatsa ho kopanngwa ha methapo, e phekola tshenyo ya boko e amanang le jwala, mme e thibela oxidation ho potoloha boko. E boetse e thusa ho ntlafatsa maikutlo le ho lwantsha mokhathala.


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